Advantageous isolated morphic Form III of the hemi-sulfate salt of AT-527 that exhibits a faster rate of dissolution over the amorphous form leading to increased bioavailability and thus efficacy for therapeutic administration in a solid dosage form to treat viral indications, as well as processes for its manufacture.

Disclosed is a process for the purification of LNnT (lacto-N-neotetraose) from a fermentation broth, the process comprises subjecting a fermentation broth to a first step of membrane filtration, thereby providing a filtrated solution, such filtrated solution is subjecting to a second step of simulated moving bed chromatography, obtaining a purified solution thereof, then subjecting this purified solution to a third step of crystallization, obtaining crystals containing the LNnT of interest, and subjecting the crystals to a fourth and final step of drying, thereby providing a highly purified powder of LNnT.

A recovery system for preparing magnesium sulfate from sulfuric acid waste solution is disclosed. The system comprises a reactor configured to remove hydrogen peroxide from the sulfuric acid waste solution and to promote a reaction between the sulfuric acid waste solution and a magnesium-based neutralizing agent to form a magnesium sulfate solution, a crystallization device configured to cool the magnesium sulfate solution and continuously crystallize magnesium sulfate crystals and a crystallization mother liquor, a dewatering device configured to separate the crystallization mother liquor from the magnesium sulfate crystals, and a drying device configured to obtain magnesium sulfate hydrates containing 0 to 7 molecules of crystalline water by controlling a drying temperature. A method for preparing magnesium sulfate using the recovery system is also disclosed.

The present invention relates to the field of dihydromyricetin extraction and purification, and in particular to a dihydromyricetin extraction and purification process. Technical problem: the dihydromyricetin extraction and purification process aims to resolve the technical problems of increased cost of subsequent impurity removing and safety risks in high-temperature centrifugation in the prior art. Technical solution: a dihydromyricetin extraction and purification process: step 1: weighing a raw material, adding an extraction solvent in an amount 5 times that of the raw material to perform reflux extraction, concentrating the filtrate to an extract, and recovering acetone; step 2: resting for crystallization for 24 hours; step 3: performing suction filtration to obtain light-green sediment underneath, and dry the sediment; step 4: adding 5%-10% activated carbon for decolorization and impurity removing; step 5: performing suction filtration; step 6: drying to obtain white powder of dihydromyricetin; and step 7: detecting a content with HPLC.