Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

The present invention relates to a method for separating off a substance from a solution, in which electromagnetic radiation is radiated into the solution, an intensity of the electromagnetic radiation which has been scattered by crystals located in the solution is detected, the detected intensity is compared with a desired intensity (I.sub.S) and the temperature of the solution is regulated depending on the difference between the detected intensity and the desired intensity (I.sub.S) in such a way that the amount of this difference is reduced. If the amount of the difference between the detected intensity and the desired intensity (I.sub.S) is less than a limiting value, a crystallization method is started in which crystals of the substance are obtained which are then separated off.

A fluid mixing unit includes a cylindrical porous body partitioning a container into a first flow space and a second flow space surrounding the first flow space. A first supply port supplies a first fluid to one of the first and second flow spaces. A second supply port provided on one end side of the container in an axial direction of the cylindrical body supplies a second fluid to the other flow space. An outlet for a mixed fluid is provided on the other end side of the container to be open only to the other flow space. Closing members are provided in a plurality of stages along the axial direction to alternately close a right and a left of the other flow space as seen in the axial direction in the other flow space. A meandering flow is formed in the other flow space to create the mixed fluid.

A method of cannabinoid preservation includes separating a cannabinoid ethanol (EtOH) mixture from a cannabis extract through a filtration process; forming a slurry by combining a crystalline compound with the cannabinoid EtOH mixture; heating and agitating the slurry in a pressurized chamber to form a colloidal cannabinoid EtOH mixture; distributing the colloidal cannabinoid EtOH mixture into a tray to form an evenly distributed mixture layer; forming an evaporation vessel for the evenly distributed mixture layer through the attachment of a detachable cover to the tray; positioning and heating the evaporation vessel within a heating chamber; performing a rapid cools process as the evenly distributed mixture layer approaches approaches saturation temperature; repeating the rapid cooling process until crystal formation is detected within the evenly distributed mixture layer; and/or removing the evaporation vessel from the heating chamber upon detection of crystal formation.

Microfluidic devices and methods for investigating crystallization and/or for controlling a reaction or a phase transition are disclosed. In one embodiment, the microfluidic device includes a reservoir layer; a membrane disposed on the reservoir layer; a wetting control layer disposed on the membrane; and a storage layer disposed on the wetting control layer, wherein the wetting control layer and the storage layer define a microfluidic channel comprising an upstream portion, a downstream portion, a first fluid path in communication with the upstream and the downstream portions, and a storage well positioned within the first fluid path, wherein the wetting control layer includes a fluid passageway in communication with the storage well and the membrane, and wherein the wetting control layer wets a first fluid introduced into the microfluidic channel, the first fluid comprising a hydrophilic, lipophilic, fluorophilic or gas phase as the continuous phase in the microfluidic channel.

The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer (10), wherein crystallization by evaporation and/or crystallization by cooling is carried out continuously on a crystal suspension in the main crystallizer in order to allow crystals of the monosaccharide to grow in the crystal suspension; separation of crystals of the monosaccharide out of the crystal suspension to obtain crystalline monosaccharide; continuous formation of a mass of crystallization magma for the main crystallizer (10) in a cascade, wherein the cascade comprises at least one first stage (13) and a final stage (15) connected in series and each stage comprises at least one pre-crystallizer (13A, 15A), wherein, in the at least one pre-crystallizer (13A) of the first stage (13), a solution is seeded with monosaccharide by means of monosaccharide seed crystals in order to obtain a pre-crystallization magma, and a mass of crystallization magma for the downstream stage (14, 15) is formed from the pre-crystallization magma by means of crystallization by cooling and/or crystallization by evaporation, and wherein a solution containing monosaccharide and a mass of crystallization magma from the upstream stage is supplied to the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) to obtain a pre-crystallization magma, and in the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) a mass of crystallization magma for the main crystallizer (10) is formed from the pre-crystallisation magma by means of crystallization by cooling and/or crystallization by evaporation; the continuous supply of a solution containing the monosaccharide and a mass of crystallization magma from the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) of the cascade to the main crystallizer (10) to provide the crystal suspension.

Process for making solid methylglycine diacetate (MGDA) alkali metal salt (a), said process comprising the steps of (A) providing a 35 to 60% by weight aqueous solution of said MGDA salt having a temperature in the range of from 50 to 90° C., (B) adding 0.01 to 2% by weight of a particulate solid with a pore volume in the range of from 0.25 to 0.75 cm.sup.3/g, determined by nitrogen adsorption in accordance with 66134:1998-02 (b), the percentage referring to the content of (a), (C) crystallizing (a), (D) removing said crystalline (a) from the mother liquor.

Microfluidic devices and methods for investigating crystallization and/or for controlling a reaction or a phase transition are disclosed. In one embodiment, the microfluidic device includes a reservoir layer; a membrane disposed on the reservoir layer; a wetting control layer disposed on the membrane; and a storage layer disposed on the wetting control layer, wherein the wetting control layer and the storage layer define a microfluidic channel comprising an upstream portion, a downstream portion, a first fluid path in communication with the upstream and the downstream portions, and a storage well positioned within the first fluid path, wherein the wetting control layer includes a fluid passageway in communication with the storage well and the membrane, and wherein the wetting control layer wets a first fluid introduced into the microfluidic channel, the first fluid comprising a hydrophilic, lipophilic, fluorophilic or gas phase as the continuous phase in the microfluidic channel.

Provided are methods of producing a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of determining the purity of a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of distributing a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of assessing suitability of migalastat hydrochloride for medical use.

A method includes supplying a supersaturated brine stream having a plurality of minerals and anti-scalant from a water treatment system to a gypsum removal system disposed within a mineral removal system. The gypsum removal system includes a gypsum reactor that may receive the supersaturated brine, may deactivate the anti-scalant such that gypsum precipitates from the supersaturated brine, and may generate a gypsum slurry having a mixture of desupersaturated brine, precipitated gypsum, and the anti-scalant in solution with the desupersaturated brine. The method also includes supplying gypsum seed crystals to the gypsum reactor. The gypsum seed crystals may precipitate the gypsum from the supersaturated brine to generate the gypsum slurry. The method also includes directing a first portion of the gypsum slurry from the gypsum reactor to a gypsum settler. The gypsum settler may reactivate the anti-scalant such that the anti-scalant absorbs onto the precipitated gypsum to remove the anti-scalant from the desupersaturated brine and may generate anti-scalant-gypsum crystals and a desupersaturated overflow having at least a portion of the plurality of minerals. The method further includes generating the gypsum seed crystals supplied to the gypsum reactor using the anti-scalant-gypsum crystals.