Methods and systems are provided for infusing a crystalline and/or porous solid with a desired fluid, particularly an antimicrobial agent, as well as infused crystalline and/or porous solids produced thereby. Solids which may be infused with an antimicrobial agent according to the invention include erythritol, table salt, table sugar, baking soda, calcium carbonate, acetic acid, ascorbic acid, and marshmallow.

A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of products comprising the concentrated product.

A method for precisely predicting phase equilibrium from existing phase equilibrium data on the basis of a wide range of phase equilibrium data including binary vapor-liquid equilibrium data; a method or apparatus for designing or controlling a component separator or a refiner using the prediction method; and a program for designing this design or control apparatus. Binary phase equilibrium measurement data is used to calculate an index of proximity ratio to critical points and infinite dilution pressure gradients. The obtained index is correlated with the infinite dilution pressure gradients to newly calculate infinite dilution activity coefficients from the respective index to infinite dilution pressure gradients correlations. The obtained infinite dilution activity coefficients values are used to predict phase equilibrium. Thus, the obtained values are used to design or control a component separator or a refiner, such as a distillation column.

A multi-stage submerged membrane distillation water treatment apparatus including: a plurality of raw water tanks arranged in multiple stages ranging from a first stage to an n-th stage and storing raw water, the raw water flowing sequentially from the first stage to the n-th stage; membrane distillation (MD) modules submerged in the respective raw water tanks and discharging a portion of the raw water as vapor; heat exchangers submerged in the respective raw water tanks and maintaining the raw water at a predetermined temperature by performing heat exchange between the raw water and vapor supplied from the respective previous-stage MD modules; a vapor generator generating and supplying high-temperature vapor to the first-stage heat exchanger; a condenser condensing vapor supplied by the n-th-stage MD module; and a raw water feeder feeding low-temperature raw water to the first-stage raw water tank via the condenser.

The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.

Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.

A MEG reclamation process includes the step of increasing above 2,000 ppm the divalent metal salts concentration of a rich (wet) MEG feed stream flowing into a precipitator. The increasing step includes routing a salts-saturated MEG slipstream from the flash separator it to the precipitator. The slipstream may be mixed with a fresh water feed stream, a portion of the rich MEG feed stream, or some combination of the two. The rich MEG feed stream also may be split into two streams, with a portion of the stream being heated and routed to the flash separator and the other portion being combined as above with the removed slipstream. The process can be performed on the slipstream after dilution and prior to entering the precipitator or after being loaded into the precipitator. Removal of the insoluble salts may be done in either a batch or continuous mode.

An apparatus for the extraction of phosphorus from wastewater that includes a precipitation module and a retention module. The precipitation module includes a crystallization vessel, one or more inlets disposed in a lower region of the precipitation module and at least one outlet disposed in an upper region of the precipitation module. The retention module includes a sedimentation vessel, at least one inlet disposed in an upper region of the retention module and at least one outlet disposed in a lower region of the retention module. At least one outlet of the precipitation module is connected to at least one inlet of the retention module and at least one outlet of the retention module is connected to at least one inlet of the precipitation module. The volume VS of the sedimentation vessel is greater than/equal to 0.6 times the volume VC of the crystallization vessel (VS≧0.6.Math.VC).

The present invention relates to a method for separating off a substance from a solution, in which electromagnetic radiation is radiated into the solution, an intensity of the electromagnetic radiation which has been scattered by crystals located in the solution is detected, the detected intensity is compared with a desired intensity (I.sub.S) and the temperature of the solution is regulated depending on the difference between the detected intensity and the desired intensity (I.sub.S) in such a way that the amount of this difference is reduced. If the amount of the difference between the detected intensity and the desired intensity (I.sub.S) is less than a limiting value, a crystallization method is started in which crystals of the substance are obtained which are then separated off.

A system including a fluid receiver defined by a crystallization chamber, three or more fluid input conduits, wherein each fluid input conduit is configured to direct a fluid into the crystallization chamber such that the fluids from the fluid input conduits converge on a single spatial coordinate (X—Y—Z) within the crystallization chamber, and a fluid outlet body portion. A process for crystallization of the chemical compound is also disclosed. Polymorphs of paracetamol, carbamazapine, ketoprofen, atorvastatin, and itraconazole also are disclosed.