The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

A method of crystallizing a solution (24) having at least one compound mixed (18) with a dissolving agent (20) is provided. The method includes performing a heating process by heating the solution (24) until a current temperature of the solution is equal to a predetermined treatment temperature, maintaining the current temperature at the predetermined treatment temperature for a predetermined treatment time period, performing a cooling process by cooling the solution (24) until the current temperature is less than the predetermined treatment temperature and a crystallization temperature of the at least one compound (18), causing formation of a plurality of crystal particles (30) of the at least one compound by cooling the solution until the current temperature is equal to a predetermined termination temperature of the at least one compound (18), and varying a particle size of each of the crystal particles (30) based on a cooling speed of the solution.

The present disclosure provides a system for extracting long chain dicarboxylic acid, the system comprising: a primary membrane filtration unit, a first crystallization unit, a first separation unit, a first dissolution tank, a secondary membrane filtration unit, a second separation unit, a second crystallization unit and a third separation unit. By the system for extracting long chain dicarboxylic acid of an embodiment of the present invention, the resulted long chain dicarboxylic acid product has a high purity, very low and even no residual alkane residue, and organic solvent-free.

The present disclosure provides a system for extracting long chain dicarboxylic acid, the system comprising: a primary membrane filtration unit, a first crystallization unit, a first separation unit, a first dissolution tank, a secondary membrane filtration unit, a second separation unit, a second crystallization unit and a third separation unit. By the system for extracting long chain dicarboxylic acid of an embodiment of the present invention, the resulted long chain dicarboxylic acid product has a high purity, very low and even no residual alkane residue, and organic solvent-free.

Method and system for the extraction of oils from a biomass with a liquid carbon dioxide using cosolvent. The system and method can be used to extract cannabinoids from Cannabis biomass by cryogenically freezing the biomass and exposing the Cannabis biomass to sub-cooled liquid carbon dioxide and capturing a first high-terpene extract fraction, and then exposing the Cannabis biomass with a mixture of superfluid carbon dioxide and a cosolvent to capture a high cannabinoid second fraction.

A system and method for producing minerals from divalent ion-containing brine stream includes rejecting sulfate from a divalent-ion rich reject stream in a first nanofiltration seawater reverse osmosis (NF-SWRO) unit, producing solid calcium sulfate dihydrate and a magnesium-rich brine stream in a first concentration unit, concentrating the magnesium-rich brine stream to a saturation point of sodium chloride in a second concentration unit, producing solid sodium chloride and a supernatant product stream in a first crystallizing unit, produce a concentrated magnesium-rich bittern stream from the supernatant product stream in a third concentration unit, and at least one of producing hydrated magnesium chloride from the concentrated magnesium-rich bittern stream in a second crystallizing unit and producing anhydrous magnesium chloride by prilling the concentrated magnesium-rich bitterns stream under a hydrogen chloride atmosphere in a dry air process unit.

A system and method for producing minerals from divalent ion-containing brine stream includes rejecting sulfate from a divalent-ion rich reject stream in a first nanofiltration seawater reverse osmosis (NF-SWRO) unit, producing solid calcium sulfate dihydrate and a magnesium-rich brine stream in a first concentration unit, concentrating the magnesium-rich brine stream to a saturation point of sodium chloride in a second concentration unit, producing solid sodium chloride and a supernatant product stream in a first crystallizing unit, produce a concentrated magnesium-rich bittern stream from the supernatant product stream in a third concentration unit, and at least one of producing hydrated magnesium chloride from the concentrated magnesium-rich bittern stream in a second crystallizing unit and producing anhydrous magnesium chloride by prilling the concentrated magnesium-rich bitterns stream under a hydrogen chloride atmosphere in a dry air process unit.

Method and system for the extraction of oils from a biomass with a liquid carbon dioxide using cosolvent. The system and method can be used to extract cannabinoids from cannabis biomass by cryogenically freezing the biomass and exposing the cannabis biomass to sub-cooled liquid carbon dioxide and capturing a first high-terpene extract fraction, and then exposing the cannabis biomass with a mixture of superfluid carbon dioxide and a cosolvent to capture a high cannabinoid second fraction.

Method and system for the extraction of oils from a biomass with a liquid carbon dioxide using cosolvent. The system and method can be used to extract cannabinoids from cannabis biomass by cryogenically freezing the biomass and exposing the cannabis biomass to sub-cooled liquid carbon dioxide and capturing a first high-terpene extract fraction, and then exposing the cannabis biomass with a mixture of superfluid carbon dioxide and a cosolvent to capture a high cannabinoid second fraction.