A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

A water filter cartridge guide includes a ring with inward facing protuberances and outward facing protuberances. The guide is operative to center a water filtration cartridge within a sump.

A water filter cartridge guide includes a ring with inward facing protuberances and outward facing protuberances. The guide is operative to center a water filtration cartridge within a sump.

A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

An apparatus is disclosed. The apparatus includes a seal having an annular body including an upper surface and a lower surface. The annular body also includes an outer side surface and an inner side surface that join the upper surface to the lower surface. The inner side surface contributes to defining an endcap-engaging surface of the seal including: a first endcap surface engaging portion that is sized for engaging a portion of an upper surface of an endcap, a second endcap surface engaging portion that is sized for engaging an outer side surface of the endcap, and a third endcap surface engaging portion that is sized for engaging a lower surface of the endcap. The annular body includes an upper portion connected to a lower portion. The upper portion of the annular body of the seal is defined by a rounded seal portion. The lower portion of the annular body of the seal is defined by a flexible tang portion and a flexible leg portion. The flexible leg portion is connected to and extends away from the rounded seal portion. The flexible tang portion is connected to and extends away from the flexible leg portion. An endcap assembly is also disclosed. A filter assembly is also disclosed.

A Spin-on filter assembly that can be used with both suction-side and pressure-side filtration systems is described. The filter assembly screws onto a filter mounting head. The filter mounting head is part of a filtration system that provides fluid to be filtered to the filter assembly. The filter assembly filters the fluid to be filtered through a filter media contained within the filter assembly and provides the filtered fluid back to the filter mounting head. The filter assembly includes an upper seal that seals the clean side of the filter media from the dirty side of the filter media when the filter assembly is connected to the filter mounting head in an installed position. The upper seal includes a sealing ridge that has an elongated shape and is flexible such that the filter assembly can be used on both pressure-side and suction side applications in filtration systems.

A Spin-on filter assembly that can be used with both suction-side and pressure-side filtration systems is described. The filter assembly screws onto a filter mounting head. The filter mounting head is part of a filtration system that provides fluid to be filtered to the filter assembly. The filter assembly filters the fluid to be filtered through a filter media contained within the filter assembly and provides the filtered fluid back to the filter mounting head. The filter assembly includes an upper seal that seals the clean side of the filter media from the dirty side of the filter media when the filter assembly is connected to the filter mounting head in an installed position. The upper seal includes a sealing ridge that has an elongated shape and is flexible such that the filter assembly can be used on both pressure-side and suction side applications in filtration systems.

A reusable fluid filter unit is disclosed. The reusable fluid filter unit encloses a filter and is removably connected to a manifold. In an embodiment, the filter unit includes an end cap that is detachable so as to replace the filter inside the filter unit. In an embodiment, the filter unit may include embossments or other structures that depress a mechanical valve in the manifold when the filter unit engages the manifold.