Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.

Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.

A method of continuous filtration of contaminants from a contaminated viscous fluid, the method may include: pumping the contaminated viscous fluid between a non-perforated surface being a first cylinder and a second perforated surface being a second cylinder disposed substantially parallel to each other at a defined first gap, moving the non-perforated surface and the perforated surface with respect to each other includes one or more longitudinal fins protruding from second cylindrical body into the first gap towards the perforated surface of the first cylindrical body thereby forming a second gap between the distal tips of the fins and the perforated surface, thereby forcing movement of the contaminated viscous fluid in a direction substantially parallel to the relative speed thereby generating a shear rate in the contaminated viscous fluid near the perforated surface in the direction substantially parallel to the relative speed.

A water purification system and method embodying a submerged conduit with a semipermeable surface, thereby leveraging water pressure to cost-effectively and energy-efficiently purify the water that permeates the semipermeable surface. A intake conduit may provide the semipermeable surface, wherein the system contemplates rotating the intake conduit so that as it rotates it engages brushes or blades that clear the semipermeable surface of obstructions.

A method for exosome separation and extraction by stacked centrifugal filtration. It is used in molecular biology and clinical examination and comprises an exosome separation and extraction kit consisting of the stacked centrifugal filtration device, an incubation buffer and a protease K. The sample to be tested is incubated at room temperature using the incubation buffer and an appropriate amount of protease K, followed by centrifugation in a centrifuge matching the stacked centrifugal filtration device. After mixing thoroughly, the retained liquid in the ultrafiltration tube is collected to obtain the exosomes. The method needs no large experimental equipments except for a centrifuge, which has a low cost and which is convenient and fast, with short operation time and the possibility of carrying out parallel operations with a large number of samples. The high purity exosomes obtained by the method can meet the demand of large-scale clinical applications.

A method for exosome separation and extraction by stacked centrifugal filtration. It is used in molecular biology and clinical examination and comprises an exosome separation and extraction kit consisting of the stacked centrifugal filtration device, an incubation buffer and a protease K. The sample to be tested is incubated at room temperature using the incubation buffer and an appropriate amount of protease K, followed by centrifugation in a centrifuge matching the stacked centrifugal filtration device. After mixing thoroughly, the retained liquid in the ultrafiltration tube is collected to obtain the exosomes. The method needs no large experimental equipments except for a centrifuge, which has a low cost and which is convenient and fast, with short operation time and the possibility of carrying out parallel operations with a large number of samples. The high purity exosomes obtained by the method can meet the demand of large-scale clinical applications.

The present invention relates to a filtration device comprising: at least one enclosure (1; 1A, 1B; 1A, 1B, 1C, 1D) defining a longitudinal axis, said enclosure being obstructed at each end by at least one sealing plate (2A, 2B; 2C, 2D), at least one filtration disc (4) that is rotated and at least one spacer (10) placed between each filtration disc (4), said spacer (10) defining an inter-disc space (10A), at least one hollow rotation shaft (3; 3A) that rotates said at least one filtration disc (4), said shaft having at least one port (33) adapted to collect filtrate (11A, 11B), said filtration disc (4) and said spacer (10) being arranged on said at least one rotation shaft (3; 3A, 3B) inside said enclosure (1; 1A, 1B; 1A, 1B, 1C , 1D), characterised in that said enclosure (1; 1A, 1B; 1A, 1B, 1C, 1D) is passed through by said at least one rotation shaft (3; 3A), and said rotation shaft (3; 3A) is driven by at least one separate rotation means (5, 5A, 5B, 5C) on at least one of the ends of said shaft, said rotation means and said rotation shaft being coaxial, and in that the device comprises at least two separate discharge means (13A, 13B) for the filtrate (11A, 11B), said discharge means being located on said rotation shaft outside said enclosure.

The present invention relates to a filtration device comprising: at least one enclosure (1; 1A, 1B; 1A, 1B, 1C, 1D) defining a longitudinal axis, said enclosure being obstructed at each end by at least one sealing plate (2A, 2B; 2C, 2D), at least one filtration disc (4) that is rotated and at least one spacer (10) placed between each filtration disc (4), said spacer (10) defining an inter-disc space (10A), at least one hollow rotation shaft (3; 3A) that rotates said at least one filtration disc (4), said shaft having at least one port (33) adapted to collect filtrate (11A, 11B), said filtration disc (4) and said spacer (10) being arranged on said at least one rotation shaft (3; 3A, 3B) inside said enclosure (1; 1A, 1B; 1A, 1B, 1C , 1D), characterised in that said enclosure (1; 1A, 1B; 1A, 1B, 1C, 1D) is passed through by said at least one rotation shaft (3; 3A), and said rotation shaft (3; 3A) is driven by at least one separate rotation means (5, 5A, 5B, 5C) on at least one of the ends of said shaft, said rotation means and said rotation shaft being coaxial, and in that the device comprises at least two separate discharge means (13A, 13B) for the filtrate (11A, 11B), said discharge means being located on said rotation shaft outside said enclosure.

An apparatus for filtration has a feed of sludge, containing liquid, solids and gases fed into a tank, the tank containing at least one spinning separation filter comprising a filter cone set having a filter screen, and a barrier cone, arranged roughly in parallel, and defining a conical workspace between them, the conical workspace having a peripheral opening to the tank and a central opening communicating with the interiors of one or more hollow shafts supporting the barrier cone and the filter cone, the upper shaft supporting the barrier cone having an upper axial channel for the exit of gases, the lower shaft supporting the center of the filter cone having a lower axial channel for the exit of liquid or oil, motor means for producing rotation in said at least one spinning separation filter, and a filtrate liquid reservoir located underneath the filter cone for capturing the filtrate passing through the filter screen.

An apparatus for filtration has a feed of sludge, containing liquid, solids and gases fed into a tank, the tank containing at least one spinning separation filter comprising a filter cone set having a filter screen, and a barrier cone, arranged roughly in parallel, and defining a conical workspace between them, the conical workspace having a peripheral opening to the tank and a central opening communicating with the interiors of one or more hollow shafts supporting the barrier cone and the filter cone, the upper shaft supporting the barrier cone having an upper axial channel for the exit of gases, the lower shaft supporting the center of the filter cone having a lower axial channel for the exit of liquid or oil, motor means for producing rotation in said at least one spinning separation filter, and a filtrate liquid reservoir located underneath the filter cone for capturing the filtrate passing through the filter screen.