A water treatment device is provided with a separation membrane device having a separation membrane for concentrating dissolved components and dispersed components from water to be treated and obtaining permeated water; a first deposit detecting unit provided in a non-permeated water branch line branched from a non-permeated water line for discharging non-permeated water in which dissolved components and dispersed components have been concentrated, using part of the non-permeated water that has branched off as a detection liquid, and having a first separation membrane for detection in which the detection liquid is separated into permeated water for detection and non-permeated water for detection; and first flow rate measuring devices for separated liquid for detection that measure the flow rates of one or both of the permeated water for detection and the non-permeated water for detection separated by the first separation membrane for detection.

The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.

The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.

A dual-filter dual-integrity test conduit assembly allows for in-situ testing of both filters with separate, duplicate systems for membrane integrity so that if the first tester filter fails, the second filter may be tested with a different, but identical method with its own gauges and nitrogen supply so as to further isolate malfunctions of the filter integrity test equipment as a cause for erroneous batch failures.

A polyamide (PA) nanofiltration (NF) membrane and a preparation method thereof by regeneration from a scrapped microfiltration (MF) membrane are provided. The method adopts a cleaning-repairing-interfacial polymerization upgrading strategy, where, sodium hypochlorite and oxalic acid are used for deeply cleaning a scrapped MF membrane. PDA is used as a repairing agent to construct a reaction platform on the membrane surface, and finally a reaction system of piperazine and trimesoyl chloride (TMC) are used to form a PA NF membrane with a PA active layer. The repairing can construct a coating with a given thickness and prominent hydrophilicity on the membrane surface, which provides favorable base membrane conditions for upgrading and preparing an NF membrane.

A testing apparatus employs an interface module removably attached to a filter testing device. The interface module includes a first flowpath communicating with an outlet of the testing device and a housing of the filter device, a first valve disposed in the first flowpath, a second flowpath communicating with the housing of the filter device and an exhaust, a second valve disposed in the second flowpath, and an enclosure enclosing the first flowpath, the first valve, the second flowpath, and the second valve. The interface module is cleanable and/or sterilizable, and replaceable. A filter integrity testing method uses an interface module to prevent contamination of the testing device and cross-contamination of different filter devices and avoid liquid ingress into the testing device.

A testing apparatus employs an interface module removably attached to a filter testing device. The interface module includes a first flowpath communicating with an outlet of the testing device and a housing of the filter device, a first valve disposed in the first flowpath, a second flowpath communicating with the housing of the filter device and an exhaust, a second valve disposed in the second flowpath, and an enclosure enclosing the first flowpath, the first valve, the second flowpath, and the second valve. The interface module is cleanable and/or sterilizable, and replaceable. A filter integrity testing method uses an interface module to prevent contamination of the testing device and cross-contamination of different filter devices and avoid liquid ingress into the testing device.

A membrane defect inspection method is for a membrane module set including a plurality of membrane modules connected in parallel under a straight pipe portion of gas detection piping extending in a horizontal direction and communicating with primary spaces in the plurality of membrane modules to which raw water is supplied or secondary spaces. The method includes a gas injection process where gas is injected into spaces opposite to the primary spaces or the secondary spaces communicating with the gas detection piping while the gas detection piping is filled with water, and an echo detection process where an ultrasonic sensor is brought into contact with an end portion of the straight pipe portion of the gas detection piping, and a reflected wave of an ultrasonic wave transmitted from the ultrasonic sensor is detected.

A method for assessing a state of fouling of a reverse osmosis system is provided. The method includes deriving a plurality of impedance values from a low frequency region of an electrical impedance spectrum of a reverse osmosis membrane comprised in the reverse osmosis system, and determining a state of fouling of the reverse osmosis system based on the plurality of derived impedance values. Use of the method for in-situ monitoring of fouling on a reverse osmosis membrane, and an apparatus for assessing a state of fouling of a reverse osmosis system are also provided.

A method for assessing a state of fouling of a reverse osmosis system is provided. The method includes deriving a plurality of impedance values from a low frequency region of an electrical impedance spectrum of a reverse osmosis membrane comprised in the reverse osmosis system, and determining a state of fouling of the reverse osmosis system based on the plurality of derived impedance values. Use of the method for in-situ monitoring of fouling on a reverse osmosis membrane, and an apparatus for assessing a state of fouling of a reverse osmosis system are also provided.