This present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process of preparing highly concentrated antibody compositions. and highly concentrated antibody products.

Disclosed is a method for removing factor XI (FXI) during plasma protein purification, more specifically a method for removing FXI including dialyzing and concentrating a plasma protein fraction II paste containing FXI and a plasma protein, and then removing the FXI using a ceramic-based cation exchange resin. The method for removing factor XI (FXI) can improve removal efficiency of impurities and thrombogenic substances, thereby producing stable plasma proteins with improved quality.

The present invention provides an improved process for isolating 2,4-bis-(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazine (DIOPAT) from an aqueous alkaline mixture M having a pH of 10 or more and comprising the 2,4-bis-(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4-dihydroxybenzophenone, and aluminum salts, wherein the process comprises a nanofiltration step, a precipitation step, and a further filtration step.

A method for producing an ethanol solution includes obtaining, from a starting liquid, a liquid feed having less than by weight of constituents and having 3% to 25% by weight of ethanol, supplying the liquid feed to a feed stream inlet of a reverse osmosis separation system having a first pass, wherein (i) each pass has an reverse osmosis membrane filtration unit, each membrane filtration unit having an ethanol rejection percentage of between 50% to 99%, and (ii) each pass has the feed stream inlet for a feed stream, a permeate stream outlet for a permeate stream, and a retentate stream outlet for a retentate stream, operating the system to maintain pressure in one of the membrane filtration units in a range of 1,200 to 4,000 psi, and obtaining retentate that is enriched with ethanol, the retentate differs from the starting liquid by absence of the removed constituents.

A feedstock processing system extracts a product from a solid using a CTSE system comprising a plurality of continuous stirred tank extraction stages arranged in fluid communication with each other in series such that effluent from one stage flows to a next stage in the series. One of the stages has an inlet to allow a measured amount of liquid solvent and the solid to be introduced to the continuous stirred tank extraction stage. The stage mixes the solid with the introduced solvent to form a homogeneous slurry to enable the product associated with the solid to be extracted with the solvent. A solid—liquid separator is arranged in fluid communication with the continuous stirred tank extraction stages, and receives an effluent from one of the stages and separates the liquid solvent containing the product from the solid to form a product-containing liquid and a product-depleted solid.

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

Disclosed herein is a method for recovering an acid or a base during a metal extraction process. The method comprises contacting a feed stream comprising the acid or base and the metal with an ultrafiltration membrane to produce an ultrafiltration retentate and an ultrafiltration permeate, and contacting the ultrafiltration permeate with a nanofiltration membrane. The nanofiltration retentate produced comprises a majority of the metal from the feed stream, and the nanofiltration permeate produced comprises a majority of the acid or base from the feed stream. Also disclosed herein is a recovery apparatus for recovering an acid or a base during a metal extraction process.

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

A process for concentrating amine water is achieved by dehydrating the amine water by membrane distillation at a temperature ranging from 30° C. to 95° C. and at a pressure ranging from 1.0 bar to 1.5 absolute bar.

This specification describes a method for lowering the content of monovalent ions in a final concentrate of a nanofiltration system relative to a brine and a corresponding nanofiltration system. The nanofiltration system comprises at least three stages of nanofiltration, wherein the concentrate from each segment flows into the next segment. A feed stream is sent into one stage to generate a concentrate stream, and a first portion of the concentrate stream is recirculated to the one stage. The pH of the feed stream is controlled in a range of 2-7. The temperature of the feed stream is in a range of 20-60° C. The feed stream includes the recirculated concentrate stream and at least part of a concentrate generated from an upstream stage. The method and the system described herein can reduce the concentration of monovalent ions in the final concentrate during a nanofiltration separation process.