Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.

Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.

A turbocharger includes a turbocharger housing having an impeller housing comprising a circular cross-section. A main nozzle is disposed within the turbocharger housing communicating a first portion of a fluid stream to a first volute. A first auxiliary channel and a first auxiliary nozzle communicating a second portion of the fluid stream to the first volute. The first auxiliary nozzle is downstream of the main nozzle. A second auxiliary channel and a second auxiliary nozzle communicate a third portion of the fluid stream to the first volute. The second auxiliary nozzle is downstream of the first auxiliary nozzle. A valve assembly is selectively coupling the first auxiliary channel to the first auxiliary nozzle and the second auxiliary channel to the second auxiliary nozzle.

Method and apparatus are disclosed for maximizing the generation of large-scale renewable energy (LSRE) by pressure-enhanced osmosis (PEO) and synergistic effects, in which a PEO module is designed by increasing the maximum power generation by increase of the dilution factor β to enhance a power output beyond ten times of the conventional PRO method, and even more power can be generated by the PEO method by incorporation with synergistic effects to form two types of PEO systems: (1) a surficial PEO system, in which the synergistic effects are achieved through combined effects of FO and nanofiltration (NF) or ultrafiltration (UF), and application of an energy exchange and fluid recovery device for re-concentration and reuse of the draw solution, (2) a subsurface PEO system, synergistic effects are achieved through application of the gravitational potential, application of waste heat from power generation, and application of an uplift chamber.

A predictive system for monitoring fouling of membranes of a desalination or water softening plant includes ultrafiltration (UF) membranes, reverse osmosis (RO) membranes, and/or nanofiltration (NF) membranes. In addition, the system includes one or more UF skids including a plurality of UF units. Each UF unit contains therein a plurality of UF membranes. Further, the system includes one or more RO/NF skids including one or more RO/NF arrays. Each of the one or more RO/NF arrays includes a plurality of RO units, with each RO unit containing therein a plurality of RO membranes, a plurality of NF units, with each NF unit containing therein a plurality of NF membranes, or a combination thereof. Still further, the system includes UF sensors and/or RO/NF sensors. The system also includes a controller comprising a processor in signal communication with the UF sensors and/or the RO/NF sensors.

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

An apparatus that treats salt-containing water by reverse osmosis, in which the salt-containing water is separated into a permeate stream and a concentrate stream, includes an inlet for the salt-containing water; an outlet for the permeate; an outlet for the concentrate, and a reverse osmosis device, wherein the inlet and the outlets are integrated into a base unit adapted for installation in a positionally fixed manner, and the reverse osmosis device is an exchangeable unit detachably connected to the base unit.

A turbocharger includes a turbocharger housing having an impeller housing comprising a circular cross-section. A main nozzle is disposed within the turbocharger housing communicating a first portion of a fluid stream to a first volute. A first auxiliary channel and a first auxiliary nozzle communicating a second portion of the fluid stream to the first volute. The first auxiliary nozzle is downstream of the main nozzle. A second auxiliary channel and a second auxiliary nozzle communicate a third portion of the fluid stream to the first volute. The second auxiliary nozzle is downstream of the first auxiliary nozzle. A valve assembly is selectively coupling the first auxiliary channel to the first auxiliary nozzle and the second auxiliary channel to the second auxiliary nozzle.

Biocide can be controllably added to a feed stream for a membrane. In some examples, the feed stream is separated into a primary feed stream and a secondary feed stream, for example, with the secondary feed stream having a lower flow rate than the primary feed stream. The secondary feed stream may be used to monitor and control the addition of the biocide, which is then diluted when the secondary feed stream is combined with the primary feed stream to form a combined stream for delivery to the membrane.

Biocide can be controllably added to a feed stream for a membrane. In some examples, the feed stream is separated into a primary feed stream and a secondary feed stream, for example, with the secondary feed stream having a lower flow rate than the primary feed stream. The secondary feed stream may be used to monitor and control the addition of the biocide, which is then diluted when the secondary feed stream is combined with the primary feed stream to form a combined stream for delivery to the membrane.