A gas separation membrane module includes at least one hollow fiber membrane element and a casing. The hollow fiber membrane element includes hollow fiber membranes and a cylindrical body. The cylindrical body extends in a longitudinal direction of the hollow fiber membranes, and accommodates the hollow fiber membranes. The hollow fiber membrane element includes sweep gas introduction ports and mixed gas discharge ports. A first supply chamber, a first discharge chamber, a second supply chamber, and a second discharge chamber are positioned between the casing and the hollow fiber membrane element. The first supply chamber, the first discharge chamber, the second supply chamber, and the second discharge chamber are partitioned off from each other.

A priming subsystem of a cell processing system carries out a method for priming a spinning membrane separator having an inlet and first and second outlets. The method includes opening a first selectable junction disposed between a priming fluid container and the inlet to open a path between the priming fluid container and the inlet, operating a first pump coupled to the first outlet to draw priming fluid from the priming fluid container into the spinning membrane separator, and closing the first selectable junction and a second selectable junction coupled to the second outlet after drawing the priming fluid into the spinning membrane separator. The method further includes operating the first pump after the first selectable junction is closed to draw a vacuum, and opening the first selectable junction after drawing the vacuum.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

A system for cleaning feed water of variable quality, the system comprising an inlet for selectively delivering feed water to one or other of at least two feed chambers, each feed chamber having a delivery pipe for delivering feed water to a reverse osmosis or nanofiltration; a pump to deliver the feed water from one of the chambers through its associated delivery pipe to the reverse osmosis or nanofiltration to create a concentrated feed stream and a product water stream; return pipes for selectively returning the concentrated feed stream to one or other of the at least two feed chambers; a product water outlet for removal of the product water; and means for switching the delivery of the concentrated feed stream between the selectable return pipes upon detection of a predetermined reduction in efficiency within one or another of the feed chambers.

A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.

The present concentration device includes a membrane module having a first and a second flow paths that are separated by a semipermeable membrane, the module including a U-shaped tube in which the semipermeable membrane is disposed, a first flow-path-inlet and a first flow-path-outlet connection parts, and a second flow-path-inlet and a second flow-path-outlet connection parts, the device including an introducing unit for introducing a subject solution with a predetermined pressure into the first flow path from the first flow-path-inlet connection part, separating the subject solution into a concentrate and a permeate through the semipermeable membrane, passing the permeate through the second flow path, draining the concentrate from the first flow-path-outlet connection part, introducing the subject solution with a pressure lower than the predetermined pressure into the second flow path from the second flow-path-inlet connection part, and draining a diluent diluted with the permeate, from the second flow-path-outlet connection part.

A separation device includes a membrane separation module (10), an adsorption module (20), and a gas intake module (30). The membrane separation module includes a first housing (110), and a membrane assembly (130) disposed in the first housing. The first housing has a first gas inlet (121), a first gas outlet (122), and a retentate gas outlet (123). The membrane module has a permeate gas outlet, the permeate gas outlet being in communication with the first gas outlet. The adsorption module has a second housing (210) and an adsorbent layer (230) disposed in it. The second housing is disposed on the first housing and has a second gas inlet (221), a second gas outlet (222), and a desorption gas outlet (223). The second gas inlet is in communication with the first gas outlet. The gas intake module has a third gas outlet (321) in communication with the first gas inlet.

A fiber bundle liquid-liquid contactor may comprise: a vessel comprising: a first inlet; a second inlet; a mixing zone arranged in the vessel to receive a first liquid from the first inlet and a second liquid from the second inlet, wherein the mixing zone comprises an inductor fluidically coupled to the inlet for the second liquid; and an extraction zone comprising a fiber bundle arranged in the vessel to receive the first liquid and the second liquid from the mixing zone.

In a first membrane filtration module comprises a membrane module comprising a plurality of permeable hollow membranes; a fluid distribution device adapted to removably surround at least a portion of the membranes of the membrane module, the fluid distribution device comprising a plurality of through-hole openings for distributing a fluid, and the fluid distribution device adapted to distribute a flow of fluid along a surface of the permeable hollow membranes. In a second membrane filtration device comprises a membrane module comprising a plurality of permeable hollow membranes, each of the permeable hollow membranes having a surface; and a gas distribution device: adapted to distribute gas bubbles to the surface of the permeable hollow membrane, adapted to removably surround at least a portion of the plurality of permeable hollow membranes, and defining a plurality of through openings for distributing the gas bubbles to the membranes.

A method of increasing the rate by which a dissimilar material separates from an aqueous-based fluid mixture is disclosed. The method includes the step of passing an aqueous-based fluid through a magnetically conductive conduit having magnetic energy directed along the longitudinal axis of the magnetically conductive conduit and extending through at least a portion of the aqueous-based fluid mixture thereby providing a conditioned fluid medium. The conditioned fluid medium is separated into at least two distinct phases in a ceramic membrane filtration apparatus downstream of the magnetically conductive conduit, wherein at least one dissimilar material separates from the conditioned fluid medium at an increased rate as compared to a rate of separation of at least one dissimilar material from an aqueous-based fluid mixture prior to passing through the magnetically conductive conduit.