A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).

A cleaning-in-place method includes terminating a cleaning-in-place cycle if a deviation of a currently detected value of a backwash hydraulic parameter (P) from a value of the same backwash hydraulic parameter (P) detected in a previous backwash cycle (32, 34, 36 38) in the same cleaning-in-place cycle exceeds a predefined deviation limit value. A filter device is provided having a control device for carrying out a respective cleaning-in-place method.

Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.

Disclosed herein is a water purifying system, including: a raw water tank configured to store raw water; a filter unit configured to include a plurality of filtration modules for purifying the raw water and a plurality of valves for feeding or cutting off the raw water; a raw water pump configured to feed the raw water from the raw water tank to the filter unit; and a backwash module configured to feed backwash water to the filter unit, in which some of permeate water permeated by the filter unit is fed to the backwash module to be used as the backwash water and a feed pressure of the backwash water is fed by the raw water pump.

A microorganism recovering method high in recovering efficiency is provided. A microorganism recovering method of recovering microorganisms from a liquid sample includes filtering out microorganisms from the liquid sample through a filtration apparatus, the filtration apparatus including a first end and a second end, the filtration apparatus being configured to receive the liquid sample at the first end and being configured to discharge from the second end filtrate generated through the filtering out microorganisms and recovering the microorganisms filtered out by the filtration apparatus together with a culture medium by feeding the culture medium from the second end to the first end.

A method for selectively cleaning a flushable filter system that includes a first filter unit and a second filter unit each of which is configured to purify unpurified liquid into purified liquid, the method comprises the steps of: operating the flushable filter system such that one of the first filter unit and the second filter unit is cleaned, while the other of the first filter unit and the second filter unit produced the purified liquid that is used to back flush the one of the first filter unit and the second filter unit that is being cleaned.

A conditioning system for a filter module is disclosed. The conditioning system may generally include an inlet, a heat exchanger, a magnetically levitated pump, a channel provided to bypass the heat exchanger, a controller, an outlet, and a base. The system may have components lined with corrosion-resistant materials. A method of conditioning a filter module is also disclosed. The method may generally include measuring TOC in a source of ultrapure water, heating the ultrapure water, rinsing a filter module with the heated water, flushing the filter module with ambient temperature water, and repeating the rinsing with heated water and flushing with ambient temperature water. A method of facilitating conditioning of the filter module is also disclosed. The method may generally include providing a portable filter module conditioning system and providing instructions for installation or use.

A novel multi-stage reverse osmosis system is proposed that allows for following benefits a) reduction in pressure-loss while achieving optimum cross-flow velocities and therefore reducing energy consumption of 4-10%; b) increased flux balance between stages resulting in reduced fouling of the first stage; c) disruption of scale forming conditions resulting in reduced scaling of the last stage; d) reduction in scale potential of the concentrate valve; e) reduction in downtime for CIP by proactively disrupting scaling or fouling through several innovative methods; f) ease-of and effectiveness-of CIP with reduced number of valves and g) to keep system operational via isolation of the last stage for maintenance while the keeping remaining system in production mode. All the above improvements are achieved with process-flow and operational characteristics defined in the Specifications and Claims.

The present disclosure provides for a continuous membrane separator bypass system and a continuous filtration separator system and methods of using the systems in the separation of liquid-liquid mixtures and filtration of process liquids. The methods and apparatus are useful for the production of fine chemicals and pharmaceuticals, particularly using Integrated Continuous Manufacturing (ICM), but can also be integrated with other manufacturing processes, such as batch and semi-continuous processes.

A sanitizing filter for sanitizing a residential water filtering system has a water filter assembly including a cartridge operable for removable attachment to the water filter assembly. When the cartridge is attached to the water filter assembly, a water flow passes into the cartridge, mixes with sanitizing media within the cartridge, and passes back into the water filter assembly. The residential water filtering system is then filled and flushed repeatedly and the mixture of water and sanitizing media sanitizes the portions of the system that are downstream from the sanitizing filter.