An electrochemical device comprises a first type of membrane disposed between first and second reservoirs containing an input solution, and a second type of membrane, different from the first type, is disposed between a first redox-active electrolyte chamber and the first reservoir and disposed between a second redox-active electrolyte chamber and the second reservoir. The first type of membrane and one of the second type of membranes form a membrane pair and the pair has an area specific resistance below y=5065.3x.sup.3−1331.1x.sup.2+90.035x+39 Ohm cm.sup.2 when the pair is equilibrated in an electrolyte and for at least part of a range where 0<x<0.4 and x is the mass fraction of salt in the electrolyte.

A priming subsystem of a cell processing system carries out a method for priming a spinning membrane separator having an inlet and first and second outlets. The method includes opening a first selectable junction disposed between a priming fluid container and the inlet to open a path between the priming fluid container and the inlet, operating a first pump coupled to the first outlet to draw priming fluid from the priming fluid container into the spinning membrane separator, and closing the first selectable junction and a second selectable junction coupled to the second outlet after drawing the priming fluid into the spinning membrane separator. The method further includes operating the first pump after the first selectable junction is closed to draw a vacuum, and opening the first selectable junction after drawing the vacuum.

A method of electrochemically treating a hydrocarbon-bearing formation is provided. The method includes electrochemically treating an aqueous fluid to provide a first fluid having a first electrochemical potential and a second fluid having a second electrochemical potential. The first electrochemical potential the second electrochemical potential have opposite signs. The method then includes introducing an amount of the first fluid into the hydrocarbon bearing formation, and then an amount of a spacer fluid is introduced into the hydrocarbon-bearing formation. An amount of the second fluid may be optionally introduced into the formation. The steps of introducing the fluids are repeated until an end point is reached. A system for electrochemically a hydrocarbon-bearing formation is also provided.

Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds are adapted to interact with other equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also can be used in conjunction with one or more sensors such as pressure and conductivity sensors that interact with the controller or are connected to a separate user interface. An aseptic environment obtains avoiding or reducing cleaning and quality assurance procedures.

A separation membrane module may decrease a bending load applied to a support member supporting ends of tubular separation membranes and omission of a seal member between the outer circumferential surface of the support member and the inner circumferential surface of a housing. The separation membrane module may include a tubular housing, tubular separation membranes arranged in a longitudinal direction of the housing, end tubes connected to lower ends of the tubular separation membranes, a support box supporting the end tubes, and a backpressure chamber below the support box. The tubular separation membranes may be in communication with a support box collection chamber. A nozzle disposed on the support box may extract permeated fluid. A chamber and the backpressure chamber are in communication via a gap between the support box outer circumferential surface and the inner circumferential surface. The chamber and backpressure chamber have substantially the same pressure.

A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

A membrane filter configured to filter a liquid, the membrane filter including a base element including at least one membrane carrier that is externally flowable by the liquid and a gas; hollow fiber membranes respectively including lumen and attached at a top of the at least one membrane carrier wherein a liquid permeate is filterable from the liquid into the lumen; a one piece extruded circumferentially closed pipe that envelops the hollow fiber membranes; a gas inlet configured to let gas into a bottom of the membrane filter; at least one permeate collection cavity included in the base element and connected with the lumen and configured to collect the liquid permeate from the hollow fiber membranes; a permeate outlet included in the base element and configured to drain the liquid permeate from the at least one permeate collection cavity laterally from the base element.

A separation membrane module that is provided enables a bending load that is applied to a support member that supports ends of tubular separation membranes to be decreased and enables a seal member between the outer circumferential surface of the support member and the inner circumferential surface of a housing to be omitted. The separation membrane module includes a tubular housing 2, tubular separation membranes 3 that are arranged in a longitudinal direction of the housing 2, end tubes 4 that are connected to the lower ends of the tubular separation membranes 3, a support box 5 that supports the end tubes 4, and a backpressure chamber 16 below the support box 5. The tubular separation membranes 3 are in communication with a collection chamber 5v of the support box 5. A permeated fluid is extracted via a nozzle 5n that is disposed on the support box 5. A chamber 11 and the backpressure chamber 16 are in communication with each other via a gap between the outer circumferential surface of the support box 5 and the inner circumferential surface of the housing 2. Pressure in the chamber 11 and pressure in the chamber 16 are substantially the same.