A tangential flow filtration manifold takes a modular form for interconnection in a manifolded arrangement for aggregating a total filtration area of the aggregate filter (membrane) surface. A plurality of modular TFF cassette filters may be or stacked on the TFF manifold such that it allows the number of interconnected filters, as well as the membrane surface area within each cassette, to be readily reconfigured. A single output, or filtrate connection on the TFF manifold simplifies fluidic plumbing connections for directing and gathering the filtrate (permeate) produced as output.

Forward osmosis membrane vessels, and particularly stackable forward osmosis membrane vessels, are provided as well as systems and methods thereof. The forward osmosis membrane vessel has a body, a strong draw solution chamber, a first and a second semipermeable membrane, and a brine chamber. The first and second semipermeable membranes each are disposed within the cavity of the body. The first and second semipermeable membranes are configured to produce diluted draw solution streams and brine streams. The brine chamber is disposed at least partially between the first semipermeable membrane and the second semipermeable membrane. The forward osmosis membrane vessel may be configured such that in a stacked configuration the brine chamber and the strong draw solution chamber of the forward osmosis membrane vessel aligns with a brine chamber and a strong draw solution chamber of an adjacent second forward osmosis membrane vessel.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Stack assembly comprising a hollow external housing having a central axis, the external housing extending from a first end to a second end and enclosing a housing space, and a membrane stack comprising a plurality of membranes, wherein the membrane slack is positionable inside the external housing and a number of side plates extending substantially parallel to the central axis, wherein each side plate of the number of side plates is associated with a side of the membrane stack and extending along the associated side and a number of sealing connectors that extend substantially parallel to the central axis and adjacent with an inner surface of the external housing, wherein each sealing connector of the number of sealing connectors is configured to connect two side plates to each other, wherein the sealing connectors and the side plates cooperate to form an enclosing structure, and wherein, in use of the stack assembly, the enclosing structure encloses the membrane stack. The invention also relates to a method for assembling a stack assembly and a method for generating energy or performing an electrodialysis process.

A method of determining flux of fluid across a filtration membrane includes: receiving an initial flow rate of fluid on a feed side; determining a change in concentration of a species between an initial concentration of a species in the fluid and a final concentration of the species in the fluid; determining a final flow rate of fluid flowing on the feed side based on the change in concentration of the species and the initial flow rate of fluid; determining flux of the fluid that has passed through the filtration membrane based on a difference between the initial flow rate of fluid and the final flow rate of fluid, and the surface area of the membrane; determining that the flux of the fluid is outside a predetermined threshold; and adjusting one or more parameters to maintain the flux of fluid through the filtration membrane below a threshold value.

A modular in vitro device can be configured as a subcutaneous absorption model. The in vitro device can include a center chamber and a matrix material configured to be included in the center chamber during measurement of absorption of a test agent. A first side chamber is configured to couple with the center chamber, with least one first side opening configured to fluidly couple with the center chamber. A first membrane is configured to be positioned between the center chamber and first side. A second side chamber similar to the first side chamber is provided, with a second membrane configured to be positioned between the center chamber and second side chamber. The center chamber, first side chamber, and second side chamber are configured to be modular for combining with the first membrane and second membrane in a lateral arrangement.

A hollow fiber membrane bundle useful for manufacturing a wide variety of hollow fiber membrane modules having different flow configurations includes hollow fiber membranes arranged around a porous support tube, a cured resin tubesheet formed at first end of the bundle, and either a cured resin nub or a cured resin tubesheet formed at a second end of the bundle. The bore(s) of the hollow fiber membranes are open at a face of the tubesheet adjacent the first end of the bundle. The tubesheet has an annular structure that encapsulates the hollow fiber membranes and the porous support tube at the first end of the bundle but which does not completely block a bore of the porous support tube, wherein the collection tube has a plurality of orifices formed therein at least at positions adjacent the nub.

A contactor module for a contactor panel includes a frame member and a contactor media coupled to the frame member. The contractor module defines a first side and a second side. The contactor media includes at least one first membrane array including a plurality of first hollow fibers extending along a first fiber axis. The at least one first membrane array defines a first axis. Further, the contactor module includes at least one second membrane array including a plurality of second hollow fibers extending along a second fiber axis. The at least one second membrane array defines a second axis. The at least one first membrane array and the at least one second membrane array is disposed such that a first inclination angle is defined between the first axis and the second axis. Moreover, the first inclination angle is greater than zero degree and less than 180 degrees.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

A method for purifying a liquid is described. A liquid feed is fed to a feed chamber. A carrier gas is fed through the liquid feed in the feed chamber to form a humidified carrier gas. A coolant is fed to a coolant chamber. The coolant chamber is separated from the feed chamber by a permeate gap chamber. The permeate gap chamber is separated from the feed chamber by a membrane that allows vapor to pass while blocking liquid flow across the membrane. The coolant chamber is separated from the permeate gap chamber by a thermally conductive plate. At least a portion of the vapor from the feed chamber that transported through the membrane is condensed by the coolant in the coolant chamber and the thermally conductive plate to form a first distillate. At least a portion of the humidified carrier gas is condensed to form a second distillate.