The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

The water dispensing device of the present invention with the given flow path of water and the control circuit configured store at least two threshold TDS values X.sub.A and X.sub.B, wherein X.sub.A is a higher TDS value than X.sub.B; and to drain water from the treatment unit through the drain line, when TDS value sensed is higher than X.sub.A, and alternately when the sensed value of TDS is less than X.sub.B then direct water from the reject line into the first recycle line; it was seen that the TDS of the output water of the device was in a constant range and the device of the present invention also contributed to minimizing the wastage of water by allowing recycling of water through the reject line of the treatment unit.

A device and a method for detecting deposits in a membrane module which produces a permeate and which comprises at least one permeable or semipermeable membrane layer. At least one polymer optical fiber for detecting deposits on the membrane layer is integrated in the membrane module such that the polymer optical fiber is in contact with at least one membrane layer. A method of detecting deposits in a membrane module producing a permeate and to a membrane module for producing a permeate from a feed stream of a fluid, in particular an aqueous solution, with the membrane module comprising a plurality of adjacently disposed or stacked sheets of a permeable or semipermeable membrane layer and with at least one polymer optical fiber being embedded or integrated in the membrane module, which polymer optical fiber is in contact with at least one sheet of the membrane layer.

The present disclosure provides apparatuses and methods that integrate sensors into bioprocessing systems and, advantageously, do not require significant re-engineering of these systems. The disclosure describes an assembly for alternating tangential flow filtration. The assembly also includes a sensor inserted into the first hemisphere of the pump housing via the port. In various embodiments, the port comprises a tri-clover connector, and the sensor is optionally inserted into the port through a plug sized to substantially occlude the port and to place the sensor in contact with a fluid in the pump housing.

A spiral wound membrane module including a specialized endcap assembly including a connecting conduit defining a passageway extending radially inward from its outer periphery, and a differential pressure sensor connected to the passageway of the connecting conduit.

A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

A spiral wound module assembly including a plurality of serially arranged spiral wound modules axially aligned within a chamber of a pressure vessel, wherein each spiral wound module includes at least one membrane envelope wound about a permeate collection tube and wherein the permeate collection tubes of each spiral wound module are in sealed fluid communication with each other and with a permeate adaptor tube that extends to a permeate outlet port, and wherein the assembly is characterized by including a monitoring system including a set of sensors in contact with the inner periphery of the permeate adaptor tube and a micro-processing unit located within the vessel and connected to the sensors.

Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.