Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Porous ePTFE articles coated with a hydrophilic coating are provided. The coating may be modified by covalent modifications to the PVOH coating. Covalent modifications may include small molecule grafting, polymer grafting to or from the PVOH backbone, crosslinking of the polymer via thermal or photochemistry, and the like, and combinations thereof. A second polymer coating may be applied onto the PVOH coating. The second polymer may be added, for example, by using a saturation coating technique such as dip coating or spray coating to saturate a PVOH coated ePTFE substrate with a second polymer carried by a fluid. Application of the second polymer may form a second conformal coating over the first PVOH coating.

The present invention provides a hollow-fiber membrane blood purification device obtained by filling a container with a hollow-fiber membrane, in which the hollow-fiber membrane contains a hydrophobic polymer, a hydrophilic polymer and a lipid-soluble substance; the amount of the lipid-soluble substance on the inner surface of the hollow-fiber membrane is 10 mg/m.sup.2 or more and 300 mg/m.sup.2 or less; and the oxygen transmission rate of the container is 1.810.sup.10 cm.sup.3.Math.cm/(cm.sup.2.Math.s.Math.cmHg) or less.

The present disclosure relates to a membrane prepared from a blend comprising i) a polysulfone, polyether sulf one or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and chon-droitin. Optionally the coating further comprises heparin. The disclosure further relates to a process for producing the coated membrane, a method of increasing the selectivity of a membrane, and to a filtration/diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

A biocompatible polymeric membrane includes pores defined between two material layers, where the first membrane material layer includes strips, and the second membrane material binds to each of the plurality of first membrane material layer strips includes a plurality of windows exposing each of the first membrane material strips. The biocompatible polymeric filtration membrane comprises pores defined by uniform passages defined by the first membrane material layer strips and the second membrane material layer within each window.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.