A blood treatment system and method controlling same are provided. The system comprises a blood pump for urging blood from an arterial or venous interface through a blood flow path; a dialyser in fluid communication with said blood flow path for ultrafiltering the blood to remove fluid therefrom; a fluid removal pump in fluid communication with said dialyser for urging ultrafiltered fluid away from said dialyser; a controller in signal communication with said blood pump; and a reversing valve for selectively reversing direction of blood flow in at least a portion of the blood flow path under signal control of said controller. The blood pump is selectively activatable under signal control of the controller.

Disclosed are tangential flow filtration (TFF) systems and methods. A system generally includes a TFF module, a control unit and one or more process-control components. In some cases, a system also includes a feed module. The control unit is electrically connected to the one or more process-control components and is configured to control the process of separation using the one or more process-control components. The systems and methods can maintain constant permeate flow rates to improve the predictability or consistence of the process, automatically switch membranes in case of membrane fouling, automatically promote membrane recovery, and/or permit operation of TFF systems in parallel with other processes in a manufacturing production.

Disclosed techniques include liquid purification with pressure vessels. Access to a set of at least two pressure vessels is obtained. The pressure vessels are interconnected using piping and computer-controlled switching valves. A first pressure vessel of the set is filled with a liquid. A second pressure vessel of the set is filled with a pressurized gas. The pressurized gas is sharp interface immiscible with the liquid. Switching valves are controlled to enable the pressurized gas in the second pressure vessel to force the liquid from the first pressure vessel into a purification chamber. Additional switching valves are controlled to enable a third pressure vessel to fill with liquid while a fourth pressure vessel is filled with purification chamber retentate. The liquid is prepurified prior to filling the first pressure vessel. The prepurifying is enabled by compressed air. The purification chamber includes a reverse osmosis chamber.

Systems, methods and apparatuses to concentrate lithium containing solutions using forward osmosis units are provided, which, for example, can include providing at least one forward osmosis unit having at least one lithium containing solution chamber having at least one first inlet and at least one first outlet, at least one brine chamber having at least one second inlet and at least one second outlet, and at least one selectively permeable membrane positioned between the at least one lithium containing solution chamber and the at least one brine chamber, and conveying a lithium containing solution through the at least one lithium containing solution chamber and a concentrated brine solution through the at least one brine chamber, said conveying causing water from the lithium containing solution to be drawn through the at least one selectively permeable membrane and into the concentrated brine solution, such that a concentrated lithium containing solution exits through the first outlet and a less concentrated brine solution exits through the second outlet.

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

The present invention relates to a computer-readable recording medium having recorded thereon a clogging location determination program for a separation membrane module, in which, in order to determine a clogging location of a separation membrane module in a fresh water generation system for obtaining treated water by filtrating water to be treated by a separation membrane module having a separation membrane, a computer is caused to function as a clogging location determination means for determining a clogging location of the separation membrane module from a resistance in a lower part of the separation membrane module, a filtration resistance of a hollow-fiber membrane, and a resistance in an upper part of the separation membrane module.

A spiral wound module assembly including a plurality of serially arranged spiral wound modules axially aligned within a chamber of a pressure vessel, wherein each spiral wound module includes at least one membrane envelope wound about a permeate collection tube and wherein the permeate collection tubes of each spiral wound module are in sealed fluid communication with each other and with a permeate adaptor tube that extends to a permeate outlet port, and wherein the assembly is characterized by including a monitoring system including a set of sensors in contact with the inner periphery of the permeate adaptor tube and a micro-processing unit located within the vessel and connected to the sensors.

A control system configured to control operation of reverse osmosis (RO) array(s), nanofiltration (NF) array(s) and/or a blending system including a control panel (CP), regulatory controllers (RCs), and a supervisory controller (SC), wherein the SC is in signal communication with the CP, and with the RCs, wherein the SC is configured to: receive user inputs from the CP, and receive inputs from RCs regarding data from sensors, wherein the RCs are in signal communication with the plurality of sensors, wherein the RCs are configured to: receive data from the sensors, provide outputs to and receive permissions from the SC, and instruct devices in response to the received permissions from the SC, and wherein the SC is configured to: monitor trends in the inputs regarding and/or predict outcomes from data received from the RCs and determine the permissions for RCs based on the monitored trends and/or user inputs from the CP.

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.