A blood filtering device has a filtration section with filter medium separating raw side and clean side. A first communication path connects raw side and a first variable blood reservoir volume; a second communication path connects raw side and a second variable blood reservoir volume coupled to a receptacle. When varying the first variable blood reservoir volume, blood contained therein flows through first communication path to raw side, plasma/serum passes through the filter medium from raw side to clean side, and residual blood flows from raw side through second communication path into the second variable blood reservoir volume. When varying the second variable blood reservoir volume, blood contained therein flows through second communication path to raw side, plasma/serum passes through the filter medium from raw side to clean side, and residual blood flows from raw side through first communication path into first variable blood reservoir volume.

The present disclosure relates to a filtration device comprising a plurality of hollow fiber membranes, a process for its production, and its use for the dead-end filtration of infusion liquids.

Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.

A centrifugal filtration device is provided. The centrifugal filtration device has filtration membrane that filtrates liquid; cartridge that supports filtration membrane and that forms liquid chamber together with filtration membrane, wherein liquid chamber holds the liquid therein; and rotating member that rotates around rotation center and that supports cartridge such that filtration membrane is positioned outward of liquid chamber with respect to rotation center. Rotating member has a path that is connected to liquid chamber, and at least a part of a liquid contact part of the path that is in contact with the liquid is formed of titanium or a titanium alloy.

A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.

Disclosed are a composite membrane and a method of manufacturing the same. More particularly, disclosed are a composite membrane, which includes a porous support and an active layer deposited on a surface of the porous support, and a method of manufacturing the composite membrane using concentration polarization of a network-nanoparticle-dispersed organic sol-containing solution on a surface of the porous support.

The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.

The invention relates to filtration system (20), comprising a tank (40) filled at least partly with water to be filtered, and at least one filtration module (30), the at least one filtration module (30) comprising at least one filter membrane (10) for filtering the water comprising a substrate (12) which is penetrated by at least one capillary (16), and at least one filtrate pipe (32) for drawing filtered water out of the tank (40), whereat the at least one filtration module (30) is arranged in the tank (40) such that the at least one filter membrane (10) is submerged at least partly in the water to be filtered. The at least one filtration module (30) is designed and arranged such that water to be filtered flows into the at least one capillary (16) and from the at least one capillary (16) through the substrate (12) into the filtrate pipe (32). The invention also relates to a method for filtering water by means of a filtration system (20) according to the invention, whereat the water to be filtered is drawn into the at least one capillary (16) and from the at least one capillary (16) through the substrate (12) into the filtrate pipe (32) and from the filtrate pipe (32) out of the tank (40).

Affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3 are disclosed. A blend or combination of spherical inorganic particles having a nominal particle size from about 5 microns to about 20 microns may be utilized. Also, the devices have a hydraulic permeability from about 200(10.sup.12 cm.sup.2) to about 700(10.sup.12 cm.sup.2). The affinity chromatography devices have a dynamic binding capacity (DBC) greater than 35 mg/ml at 10% breakthrough at a residence time of 20 seconds. Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an operating pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices and manifolds in a parallel configuration are also disclosed.

Provided is an improved filtration module assembly comprising a vessel having a filtration cartridge disposed within it and a header coupled to an end of the vessel, the header including a housing having an open-ended upper end and a lower end, and an end cap including a portion that mates with a complimentary structure defined by the inner all of the open ended upper end of the housing to removable engage with the housing and the end cap may further define a passageway for fluid to flow out of the vessel. The filtration module assembly may enable an improved manifold arrangement used to communicate fluids to and from a filtration system comprising a plurality of such modules and the configurations of the present invention may facilitate improved operation of such filtration systems.