Provided is an improved filtration module assembly comprising a vessel having a filtration cartridge disposed within it and a header coupled to an end of the vessel, the header including a housing having an open-ended upper end and a lower end, and an end cap including a portion that mates with a complimentary structure defined by the inner all of the open ended upper end of the housing to removable engage with the housing and the end cap may further define a passageway for fluid to flow out of the vessel. The filtration module assembly may enable an improved manifold arrangement used to communicate fluids to and from a filtration system comprising a plurality of such modules and the configurations of the present invention may facilitate improved operation of such filtration systems.

The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.

An ultrapure water production apparatus (1) includes an ultrafiltration membrane device (10). The ultrafiltration membrane device (10) includes a plurality of ultrafiltration membranes (11, 12) that are connected in series. The plurality of ultrafiltration membranes (11, 12) include a first ultrafiltration membrane (11) and a second ultrafiltration membrane (12) located farthest downstream among the plurality of ultrafiltration membranes (11, 12), the second ultrafiltration membrane (12) having filtration properties that are different from filtration properties of the first ultrafiltration membrane (11).

Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced.

A method of operating a filtration unit of a filtration system includes feeding, during filtration, feed water containing suspended particulate material to an inside of each of a plurality of hollow fibres through a first inlet and a second inlet of each hollow fibre while simultaneously removing a filtrate from an outside of each of the hollow fibres through an outlet of a filtration elements. In addition, the method includes feeding, during back-washing, back-wash water to the outside of the hollow fibres through the outlet of the filtration element. Further the method includes discharging, in a first back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from one end thereof. Still further, the method includes discharging, in a second back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from the other end thereof.

Embodiments of the present disclosure relate generally to dead-end filtration systems and, more particularly, to pulse-modulated periodic backflush systems and methods for clearing fouling layers in dead-end filtration systems. In some embodiments, a controller may control the flow of fluid in the system from cycling from a forward flow to a reverse flow. In some embodiments, the controller may cycle from forward to reverse flow based on a volumetric flow ratio. Embodiments of the present disclosure describe optimal volumetric flow ratios for optimizing the break of cake in a dead-end filtration system. Embodiments of the present disclosure describe optimal volumetric flow ratios for optimizing recovery percentages of targeted particles.

A method of operating a filtration unit of a filtration system includes feeding, during filtration, feed water containing suspended particulate material to an inside of each of a plurality of hollow fibres through a first inlet and a second inlet of each hollow fibre while simultaneously removing a filtrate from an outside of each of the hollow fibres through an outlet of a filtration elements. In addition, the method includes feeding, during back-washing, back-wash water to the outside of the hollow fibres through the outlet of the filtration element. Further the method includes discharging, in a first back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from one end thereof. Still further, the method includes discharging, in a second back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from the other end thereof.

Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.5 is satisfied in a case where an average hole diameter of the first filter membrane is A and an average hole diameter of the second filter membrane is B; or an average hole diameter of the first filter membrane is 20 ?m or smaller, and the second filter membrane is an ultrafiltration membrane.

Disclosed herein is a hollow fiber membrane module provided with a hollow fiber membrane bundle, a case in which the hollow fiber membrane bundle is contained, a fixation part which affixes the hollow fiber membrane bundle within the case and divides the space inside the case into a first space that is outside the hollow fiber membranes and a second space that is in communication with the insides of the hollow fiber membranes, and a partition plate which divides the first space into a first region and a second region.

The present invention provides a separation membrane element packed with a rugged sheet object, the separation membrane element being effective in attaining both stabilization of steps for producing the separation membrane element and an increase in fresh-water production rate. The present invention relates to a separation membrane element including: a separation membrane; and a permeate-side channel material disposed on a permeate side of the separation membrane, in which the permeate-side channel material is a porous sheet object having a recess and a protrusion on at least one face thereof, the recess being a coarsely porous region and the protrusion being a densely porous region.