Disclosed herein is a single pass cross flow diafiltration system comprising: a filtration module having; two or more filtration segments fluidly connected in series, each having an upstream side and a downstream side; wherein each filtration segment comprises hollow fiber filter membranes, and wherein each filtration segment has a selected length; wherein the hollow fiber filter membranes of each filtration segment have a selected inner diameter; wherein the selected inner diameter of each filtration segment may be the same or different, provided that at least one selected inner diameter differs from another selected inner diameter, and provided that the two or more filtration segments are arranged such that no selected inner diameter in a given filtration segment is larger on the upstream side; one or more pumps, mounted to urge fluid flow; and one or more points of introduction of a diadiluent, each of said points of introduction being fluidly connected to an upstream filtration segment.

A feed of at least one of (a) a source liquid including a solvent with a dissolved impurity and (b) a retentate of the source liquid is pumped in a substantially closed loop through a liquid-separation module. The liquid-separation module includes a membrane that passes at least partially purified solvent to a permeate side of the membrane while diverting the impurity in a retentate on the retentate side of the membrane. The purified solvent is extracted from the permeate side of the membrane; and the retentate from the liquid-separation module is pumped to or through a pressurized reservoir with a variable volume for the feed component and recirculated as a component of the feed. Over time, the volume for the feed is reduced and the pressure applied to the feed in the reservoir is increased to balance against an increasing difference in osmotic pressure across the membrane.

A source liquid including a solvent with a dissolved impurity flows into a reservoir. The source liquid or a concentration of the source liquid is pumped from the reservoir through a pressure exchanger into an upstream side of a liquid-separation module. The module includes a membrane that at least partially purified solvent as filtrate to a permeate side of the liquid-separation module while diverting the impurity in a feed retentate on the upstream side of the liquid-separation module. The substantially pure water is extracted from the permeate side of the liquid-separation module, while the feed retentate is passed from the upstream side of the liquid-separation module through the pressure exchanger, where pressure from the feed retentate is transferred to the feed from the reservoir. The feed retentate is then passed from the pressure exchanger to the reservoir and recirculated as a component of the feed via the above steps.

The present disclosure is directed to filtering technologies that combine elements of continuous and batch NF/RO based on the constraints of the end-user facility to achieve a target balance between, for instance, recovery and power consumption, and to reduce long term operating cost of a plant. A method for extending batch operation into a second induction period with antiscalant injection is also disclosed herein, with the second induction period allowing for yet higher water recovery.

A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).

The inventive system and method comprises one or more batch closed circuit desalination (CCD) unit(s) linked by conducting lines and valves means to a pressure exchange (PE) means, such that each said CCD can be engaged periodically with said PE means for brine replacement by fresh pressurized feed, thereby, enable a continuous consecutive sequential batch desalination under fixed flow and variable pressure conditions of low energy and high recovery of unchanged flux. The inventive system and method opens the door to large scale CCD systems operated by predetermined fixed set points of pressurized feed low, cross-flow or module recovery, and system recovery, independent of each other, of infinite operational combinations and high flexibility for effective process optimization. The inventive system and method overcome former volume requirement limitations of large scale SWRO CCD installations.

A high gravity non-alcoholic beverage is disclosed having an ABV between about 0.1% to about 0.8% or between about 3% to about 6%, a real extract by weight between about 15% to about 70%, and an ethyl acetate amount between about 1 to about 500 mg/l. A method for producing the high gravity non-alcoholic beverage from a starting liquid includes providing a set of reverse osmosis pressure vessels, each pressure vessel having a feed inlet, a retentate outlet, and a permeate outlet, the set having a first pressure vessel, providing the starting liquid to the feed inlet of the first pressure vessel, adding water at a blend point when ABV content in a selected one of the permeate streams exceeds ABV content of a retentate stream at the blend point, and obtaining the high gravity non-alcoholic beverage from a selected one of the retentate streams.

Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.

Described are filter materials including a polyol ligand, such as n-methylglucamine, and/or a polyphosphonic acid ligand, which are highly effective for filtering metals or metal ions from fluids. The filter materials can be particularly useful to filter basic and acidic fluid compositions, such as those used for wet etching, removing photoresist, and cleaning steps in microelectronic device manufacturing.

The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.