The invention relates to a method for the purification of immunoglobulin and/or albumin from a sample of plasma, the method comprising mixing a sample of plasma with a medium chain fatty acid, and recovering the soluble immunoglobulin from the mixture.

A method of making depth filtration media, such as for use in a depth filter, are described. The resulting depth filtration media includes a core tube having two or more different layers. The layers can be fibers, such as polymeric or inorganic fibers, wrapped layers of a filter material, or pleated and folded layers of a filter material.

The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

A system and method for concentrating and capturing target material from a fluid sample, comprising directing a fluid sample containing a target material into a prefiltration cartridge, wherein the prefiltration cartridge further includes at least one prefilter, wherein the at least one prefilter further includes a plurality of stacked individual filters of predetermined diameters and pore sizes; directing the fluid sample from the prefiltration cartridge to a capture cartridge, wherein the capture cartridge further includes a capture filter disposed therein; capturing the target material on the capture filter; eluting the target material from the capture filter; and collecting the eluted target material.