The present invention relates to systems and methods for filtration and/or dilution of fluids, in particular for the dialysis of blood. The systems comprise a filter device (10) having a fluid chamber (18) and comprising a first lid (20) having arranged thereon a first fluid port (22). The filter device (10) further comprises a second lid (30) having arranged thereon at least a second fluid port (32). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). Also, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18).

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.

A nanoflotation system used to separate suspended solids or large settling or floating solids from water, waste water or liquids. This is accomplished through the use of submerged membranes, in combination with a number of design components comprising froth flotation, gravity settling, pre coating of the submerged membranes, spacing, of the membranes to facilitate flotation of solids to the surface or to the bottom of the containment chamber holding the submerged membranes, and membrane structures which use large diameter hollow fiber or tubular membranes and/or large pore opening membrane materials.

A process for separating a gaseous or liquid mixture by means of a separating device including a first volume and a second volume which are separated by a membrane which has selective permeability with respect to at least two components of the mixture, comprising the following steps: a) fill up the first volume of the device with the mixture to be separated; b) wait for a period of time which is in excess of the permeation lag time, but is insufficient to reach a state of equilibrium, during which time a fraction of each component of the mixture passes from the first to the second volume of the device through the membrane; and c) evacuate the first and the second volume of the device, as a result of which at least one first and one second cut of the mixture is obtained, having different molar compositions.

A method for recycling waste water containing slurry from a semiconductor treatment process; including: Filtration in which waste water containing the fresh slurry is continuously introduced into a circulation tank, during which time the mixed waste water is continuously extracted from the circulation tank, the extracted waste water is guided through an ultrafilter device and is concentrated by removing the fluid to form concentrated waste water and the concentrated waste water is introduced into the circulation tank and mixed with the contents of the circulation tank; and concentration in which the addition of fresh waste water to the circulation tank is essentially stopped when the mixed waste water is continuously extracted from the circulation tank, said extracted mixed water waster being introduced through the ultrafilter device and is concentrated by removing the fluid to form concentrated waste water and the concentrated waste water is introduced into the circulation tank.

A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path.