A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

Herein, systems and methods are disclosed including a sample acquisition component (SAC) for user-friendly sample collection, a separation component for optional separation of plasma, and one or more stabilization components for stabilizing analytes. In a particular embodiment, the system and methods are directed towards sample collection and stabilization with optional sample separation. Other embodiments can perform any combination of collection, separation, stabilization or detection.

A filtration apparatus includes a tubular casing having a longitudinal axis and first and second casing ends, a plurality of partition plates positioned in the casing and sealed thereto to thereby define an intake collection chamber between a first of said partition plates and the first casing end, a discharge collection chamber between a second of said partition plates and the second casing end, and a reject collection chamber opposite the second partition plate from the second casing end, a plurality of elongated filtration membrane stacks positioned side-by-side in the casing generally parallel to the longitudinal axis, each filtration membrane stack comprising an intake end fluidly connected to the intake collection chamber, a discharge end fluidly connected to the reject collection chamber, and a permeate channel extending between the first and second ends and fluidly connected to the discharge collection chamber. The filtration apparatus also includes an intake pipe connected to the intake collection chamber, a discharge pipe connected to the discharge collection chamber, and a reject pipe connected to the reject collection chamber. Each filtration membrane stack is made of a plurality of filtration membranes which are each sealed to a corresponding hole in a corresponding partition plate, each filtration membrane having an inlet end and an outlet end and being sealed to the corresponding hole between the inlet and outlet ends, and the outlet end being spaced apart from an adjacent partition plate located closer to the second casing end.

Spacers are attached to membranes of an array of flat plate ceramic membranes. The spacers limit bending of the membranes which can be caused by buildup of solids on the faces of adjacent membranes.

The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

The invention relates to a modular flow system having a plurality of frame elements (101, 102) configured to be combined together to form a stack for forming a functional member such as in particular a membrane distillation stage, a vapor generator, a condenser, a heat exchanger, a filter and/or a pervaporation stage, wherein the frame elements (101, 102) each include: an outer frame (39) and an inner frame (43), the inner frame (43) encasing a central inner region (40) and being surrounded by the outer frame (39), at least one first passage opening (13 to 16) arranged between the outer frame (39) and the inner frame (43) and separated from the central inner region (40) by a frame wall on a first and/or opposite second frame side of the inner frame (43), and at least one liquid passage (45, 46) provided by the frame wall and configured to distribute a liquid from the first passage opening (13) to a feeding area (40′) and/or to collect a liquid from the feeding area (40) to the first passage opening (16a, 16b)), the feeding area (40′) being aligned with the central inner region (40) but being outside and/or in front of the inner frame (43), wherein the liquid passage extends asymmetrically and/or discontinuously along the first and/or second frame side.

Herein, systems and methods are disclosed including a sample acquisition component (SAC) for user-friendly sample collection, a separation component for optional separation of plasma, and one or more stabilization components for stabilizing analytes. In a particular embodiment, the system and methods are directed towards sample collection and stabilization with optional sample separation. Other embodiments can perform any combination of collection, separation, stabilization or detection.

A spiral wound membrane module including a specialized end cap assembly including a connecting conduit defining a passageway extending radially inward from its outer periphery, and a differential pressure sensor connected to the passageway of the connecting conduit.

A spiral wound module assembly including a plurality of serially arranged spiral wound modules axially aligned within a chamber of a pressure vessel, wherein each spiral wound module includes at least one membrane envelope wound about a permeate collection tube and wherein the permeate collection tubes of each spiral wound module are in sealed fluid communication with each other and with a permeate adaptor tube that extends to a permeate outlet port, and wherein the assembly is characterized by including a monitoring system including a set of sensors in contact with the inner periphery of the permeate adaptor tube and a micro-processing unit located within the vessel and connected to the sensors.