A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module (19) modifying the composition of the fluid, a second module (21) modifying the composition of the fluid and a dwell module (20) with an inlet (8) and an outlet (10). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium (4, 14) delimiting a supply channel (2, 12) and a retentate channel (1, 11) and at least one second filter medium (5, 15) delimiting the retentate channel and a permeate channel (3, 13).

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Devices and methods for separating multi-phase fluids, comprising a first porous medium portion and a second porous medium portion. The device comprises a fluidic channel comprising an inlet; the first porous medium portion between the fluidic channel and a first auxiliary outlet; and the second porous medium portion between the fluidic channel and a second auxiliary outlet. The method comprises presenting a combined flow comprising a first fluid phase and a second fluid phase to a separator, wherein the first porous medium portion has a higher affinity for the first fluid phase than for the second fluid phase, and the second porous medium portion has a higher affinity for the second fluid phase than for the first fluid phase.

Coated crossflow filter membranes, crossflow filters comprising the coated filter membranes and crossflow filtration systems for separating material such as biological material sensitive to temperature, dissolved gases, and mechanical damage are disclosed.

A hollow fiber membrane element, comprising: a core tube comprising a side face having a plurality of pores; and a hollow fiber membrane group consisting of a plurality of hollow fiber membranes disposed around the core tube, the hollow fiber membrane element being a both open-ended type hollow fiber membrane element in which both ends of the core tube and the plurality of hollow fiber membranes are open. The hollow fiber membrane group includes a first hollow fiber membrane layer composed of a plurality of first hollow fiber membranes disposed so as to surround the core tube and a second hollow fiber membrane layer composed of a plurality of second hollow fiber membranes disposed so as to surround the first hollow fiber membrane layer, and a permeability coefficient of the plurality of first hollow fiber membranes is smaller than a permeability coefficient of the plurality of second hollow fiber membranes.

A reverse osmosis water system including a housing, a reverse osmosis cartridge, an unfiltered waterline, and a blend waterline. The housing includes an inlet and an outlet. A medial waterline transports pretreated water to the reverse osmosis cartridge. An unfiltered waterline includes a flow restrictor. A blend waterline transports a blended water mixture to the outlet. The blended waterline receives filtered water at a first flowrate from the medial waterline and unfiltered water at a second flowrate downstream of the flow restrictor. The flow restrictor provides the second flowrate at a substantially equal rate to the first flowrate.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

Provided is a filtration device exhibiting a high water treatment capacity and capable of increasing the longevity of a hollow-fiber filter, in a water purification device not requiring a purification material and requiring a high water treatment capacity. The filtration device (3) has: a housing case (15) having a water inlet unit and a water outlet unit arranged on one end side thereof; and a membrane module (17) provided inside this housing case (15). A first flow path (31) for causing raw water that has flowed in from the water inlet unit (21) to flow further to the other end side of the housing case (15) than the membrane module (17), and a second flow path (33) for causing the raw water that has flowed further to the other end side of the housing case (15) along this first flow path (31) to pass through the membrane module (17) and flow to the water outlet unit (23) are provided inside the housing case (15). A spacer (19) is provided on the upstream side of the membrane module (17) in the second flow path (33).

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter d.sub.1 of the hollow fiber membrane 31 is equal to or smaller than 150 m, a tilt angle with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60, and a ratio D.sub.1/L of an outer diameter D.sub.1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.