A cell culture bioreactor has perfusion membranes and gas transfer membranes or a gas phase in an extra-membrane space in contact with a film on the perfusion membranes. Gas transfer membranes may travel through the perfusion membranes or through the extra-membrane space. Examples with hollow fiber and flat sheet membranes are shown. One or more of the membranes optionally has a responsive surface, for example a thermo-responsive surface. In some examples, membranes are located in X-Y planes while the length of the reactor extends in a Z-direction.

The present application discloses a membrane element and a filter cartridge, wherein the membrane element comprises: a water collecting pipe; and a first membrane unit and a second membrane unit rolled on the water collecting pipe together, a waste water outlet of the first membrane unit being in communication with a raw water inlet of the second membrane unit, the waste water outlet of the first membrane unit and the raw water inlet of the second membrane unit being located a same side edge corresponding thereto when the first membrane unit and the second membrane unit are in an unrolled state. The first membrane unit and the second membrane unit may be rolled on the water collecting pipe together at one time. In this embodiment, the membrane element in the embodiment of the present application can improve a surface flow rate of the membrane element, thereby improving the anti-containment performance of the membrane and extending the service life of the membrane, while the production of pure water of the membrane element remains unchanged under the same water intake pressure.

The disclosure provides a hollow fiber liquid filter device provided with exhaust fiber membranes. The hollow fiber liquid filter device comprises a shell, a liquid inlet end, a liquid outlet end, a melt-blown fiber filter element, a hollow fiber liquid filtering part and a hollow fiber gas filtering part, wherein the liquid inlet end and the liquid outlet end are respectively connected to the upper end and the lower end of the shell, the melt-blown fiber filter element is arranged on the inner side of the shell, the hollow fiber liquid filtering part and the hollow fiber gas filtering part are respectively arranged on the inner side of the melt-blown fiber filter element, a liquid inlet is formed in the liquid inlet end, and ,a liquid outlet is formed in the liquid outlet end.

A filtering device is for obtaining a chemical liquid by purifying a liquid to be purified, and the filtering device has an inlet portion, an outlet portion, a filter A, at least one filter B different from the filter A, and a flow path which includes the filter A and the filter B arranged in series and extends from the inlet portion to the outlet portion, in which the filter A is a porous membrane containing a polyimide-based resin.

The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

A dialyzer composed of: first and second dialyzation chambers, and an intermediate chamber interposed between the first and second dialyzation chambers. Each of the chambers has a respective one of a blood inlet or outlet and a dialysate inlet or outlet arranged so that blood and dialysate flow in counter-current to one another in both chambers. The intermediate chamber is connected to form a dialysate-free blood flow passage between the blood chambers and is configured to maintain a substantially uniform blood flow.

A composition of five parts by mass of chitosan and one part graphene oxide is suspended in water. The composition may be used to form filtration layers of any size or shape and may be reinforced by additional layers. The composition may be used to construct a large filtration apparatus of any size or shape and may be used to form highly resilient, antimicrobial structures and surfaces for a variety of applications.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.