The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

A method for processing a fluid with forward osmosis process includes providing one or more tubular membranes each including a tubular nonwoven base layer on the outside of the tubular membrane forming an outer shell of the tubular membrane and providing a lumen for feed flow; a polymer substrate layer on the lumen-side of the tubular membrane comprising three regions, including a region where the polymer substrate layer is partially intruded into the tubular base layer, a region with an open macrovoid structure and a region with an asymmetrical foamy layer, where the partially intruded region forms an intermediate layer; and a functional top layer on the polymer substrate layer. The tubular base layer comprises a longitudinal weld. The method includes providing the feed flow through the lumen and providing a draw solution on the outer shell side of the tubular membrane; and processing the feed flow with the membrane.

This invention relates to various membrane-based processes and their combinations, such as Forward Osmosis (FO), Reverse 5 Osmosis (RO), Nanofiltration (NF), Ultrafiltration (UF), Membrane Bioreactor (MBR), Osmotic Distillation (OD) and Membrane Distillation (MD), for various application of dilution, concentration, dewatering, separation, purification, fractionation or extraction applications of different solvents including 10 various sources of water, wastewater, active pharmaceutical ingredients (APIs), food and beverage sources, dairy products etc. It is also applicable to all the industrial and domestic applications that involves recovering or water reclamation from inlet sources.

Apparatus and method for semi-permeable membrane cleaning in particular, applying series of pulsed water stroke, made simultaneously with osmosis backward flow causing superposed membrane directional shaking and fouling detachment. Pulsed water stroke provided by water stroke generator as several momentum sharp changes in gauge pressure and induce velocity pulse of residual brine flow. The pulsed water strokes ideally induce resonance in the membrane. Osmosis backward wash may be provided either by injection for predetermined injection time, additional solution selected in such way that net driving pressure be-comes opposite to normal osmotic operation thereby providing a backward flow of permeate towards to the side opposite to normal operation mode, so as to lift said foulant, or by throttling permeate exiting from the permeate enclosure, until the net driving pressure value become equal to zero, during application of precise synchronized and opposing brine and permeate pressure strokes thereby providing a plurality of quick RO-FO-RO process changes. These procedures allow a membrane to be kept continuously clean and operate at higher recovery.

Separation processes using osmotically driven membrane systems are disclosed generally involving the extraction of solvent from a first solution to concentrate solute by using a second concentrated solution to draw the solvent from the first solution across a semi-permeable membrane.

A spiral wound membrane element and a method for cleaning a spiral wound membrane sheet are provided. The spiral wound membrane element comprising a perforated central tube; one or more membrane sleeves, each sleeve comprising two membrane sheets enclosed at two edges around a feed spacer sheet and wrapped around the central tube; a permeate carrier sheet attached to the central tube at a first edge opposite a second edge; and a seal on third and fourth edges of the permeate carrier sheet. The method comprises introducing two solution with different solute concentration to two sides of the spiral wound membrane sheet; establishing a concentration gradient between the first and second sides; communicating a first solvent from the first side to the second side to remove a foulant located on the second side of the membrane sheet; and collecting a waste stream that contains the foulant.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

Apparatus and method for semi-permeable membrane cleaning in particular, applying series of pulsed water stroke, made simultaneously with osmosis backward flow causing superposed membrane directional shaking and fouling detachment. Pulsed water stroke provided by water stroke generator as several momentum sharp changes in gauge pressure and induce velocity pulse of residual brine flow. The pulsed water strokes ideally induce resonance in the membrane. Osmosis backward wash may be provided either by injection for predetermined injection time, additional solution selected in such way that net driving pressure becomes opposite to normal osmotic operation thereby providing a backward flow of permeate towards to the side opposite to normal operation mode, so as to lift said foulant, or by throttling permeate exiting from the permeate enclosure, until the net driving pressure value become equal to zero, during application of precise synchronized and opposing brine and permeate pressure strokes thereby providing a plurality of quick RO-FO-RO process changes. These procedures allow a membrane to be kept continuously clean and operate at higher recovery.