The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

A system for the treatment of materials, to be selected from between materials in a fluid state (1) and particles suspended in a fluid material (1), comprising at least one upper kinematic pair equipped with two mechanical elements (2a, 2b; 2a, 2c), said kinematic pair being in contact with a material in a fluid state (1) or with particles suspended in a fluid material (1); motor means (5) to generate a pre-set relative velocity (v) between the elements (2a, 2b; 2a, 2c) of said kinematic pair, and tensioning means (8) to subject said kinematic pair to a pre-set pressure (P).

The boundary layer drum mixer is an apparatus which can pass through the narrow top port of a standard chemical drum or bulk container without the need to disassemble any part of the mixer or the vessel. The invention is an enclosed system with an internal arrangement of impellers and stators which draw liquid-based media from the adjacent vessel and strategically distributes it throughout the vessel through an array of outlet ports. The strategic mixing requires low energy input, minimizes the risk of media aeration and works with a wide range of fluid levels. The apparatus imparts no net external torque, and therefore, requires no rigid mounting. The upper impeller flow positively entrains particles or liquid phases that tend to float. The lower impeller flow positively entrains particles or liquid phases that tend to sink and/or remain static in boundary layers against or near the vessel walls and base.

The present invention pertains to an oxygen dissolution device. According to the device, the oxygen and water introduced into the housing are agitated and mixed with each other by eddies and currents formed by the plurality of first smashing blades and the second smashing blades, then converted into oxygen-dissolved water having a large amount of dissolved oxygen. Therefore, an amount of oxygen which is not dissolved in the water to be waste may be decreased so as to reduce purchase costs of oxygen, as well as, when supplying the oxygen-dissolved water having a large amount of dissolved oxygen as described above to a fish farm, the amount of dissolved oxygen of the water in the fish farm may be rapidly adjusted to a level which is suitable for the farmed fish to live in.

This application discloses a stirrer with a direct drive motor comprising a stator module with a rod mounted onto a stator and a rotor module comprising a rotor encapsulated in a housing and connected to an impeller. In some embodiments the rod functions as a cooling device to prevent the stator from being overheated during stirring. The stator module and the rotor are encapsulated in their separate housing and are detachable from each other and the impeller to allow the user to clean, disinfect, maintain or repair the stator module, rotor, impeller, and coupling between the stator module and the rotor before further use. Depending on the type of impeller added, it may be used for moving, stirring, mixing, agitating, blending, aerating, homogenizing, or cutting the medium.

This application discloses a stirrer with a direct drive motor comprising a stator module with a rod mounted onto a stator and a rotor module comprising a rotor encapsulated in a housing and connected to an impeller. In some embodiments the rod functions as a cooling device to prevent the stator from being overheated during stirring. The stator module and the rotor are encapsulated in their separate housing and are detachable from each other and the impeller to allow the user to clean, disinfect, maintain or repair the stator module, rotor, impeller, and coupling between the stator module and the rotor before further use. Depending on the type of impeller added, it may be used for moving, stirring, mixing, agitating, blending, aerating, homogenizing, or cutting the medium.

The present disclosure relates to systems and methods for producing nanoparticles of a material in a working liquid. The apparatus can include a core for accelerating the working liquid and the material, wherein the core includes: a first cylinder including: a radially outer surface and a radially inner surface; and a plurality of first through holes extending from the radially inner surface to the radially outer surface of the first cylinder; a second cylinder including: a radially outer surface and a radially inner surface; and a plurality of second through holes extending from the radially inner surface to the radially outer surface of the second cylinder; wherein the second cylinder radially surrounds the first cylinder; wherein each of the first through holes and the second through holes have a smaller cross-section at the radially inner surface than at the radially outer surface.

An apparatus for mixing a liquid or pasty product. The apparatus includes a first housing part (11) and a second housing part (12) assembled together. The assembly of the first housing part (11) and the second housing (12) part forms a housing inner space (17) between an inlet (4) and an outlet (5), a cooling jacket (7) for circulation of a coolant fluid around the housing inner space (17), and a buffer jacket (9) for circulation of a clean fluid, the buffer jacket (9) being formed between the cooling jacket (7) and the housing inner space (17). The buffer jacket protects the mixed product from contamination by the coolant fluid. It also facilitates detection of leakage between the housing inner space and the buffer jacket. The invention also relates to a corresponding method.

A centrifugal dispersion device is provided. The centrifugal dispersion device includes a cylinder body, multiple rotor units, and multiple stator units. The cylinder body is internally provided with a shaft core. Each rotor unit includes a rotor inner cylinder, a rotor outer cylinder, and a rotor rib-plate. The rotor inner cylinder is fixedly sleeved on the shaft core and rotatable along with the shaft core. The rotor inner cylinder and the rotor outer cylinder cooperatively define a rotor cavity. Each stator unit includes a stator cylinder and a blocking portion. The stator cylinder is fixedly connected to an inner wall of the cylinder body. The blocking portion extends from an inner wall of the stator cylinder into a gap between adjacent two of the multiple rotor units. A first flow-passing channel is defined between the inner wall of the stator cylinder and an outer wall of the rotor outer cylinder.

Apparatus and methods for food production including a food preconditioner (228) operable to heat and partially pre-cook food ingredients, and a twin screw extruder (20) operable to further cook the preconditioned ingredients to create final food products. The extruder (20) includes a pair of hollow core extrusion screws (50, 52, 124, 126, 190) having elongated hollow core shafts (54, 128, 130, 192) equipped with helical fighting (56, 132, 134, 194) along the lengths thereof. The fighting (132, 134, 194) is also of hollow construction which communicates with the hollow core shafts (54, 128, 130, 192). The fighting (56, 132, 134, 194) also includes forward, reverse pitch sections (64, 162, 216). The extrusion screws (50, 52, 124, 126, 190) are designed to impart high levels of thermal energy into materials being processed in the extruders (20), without adding additional moisture.