A mixing device for operating biological, chemical or biochemical materials used in an assay includes a mixing member formed with a plurality of chambers, each having a sealable port provided along an edge of the mixing member. The mixing device also includes one or more compartments that are movable along the edge of the mixing member between selected ones of the sealed chambers. This compartment is operable to receive materials from and transfer materials between the chambers. Selected ones of the chambers include associated processing elements, for example, including heating and cooling elements, magnetic elements, membranes and lateral flow devices. The mixing device is also pivotable, for example, to facilitate the application of gravity force in the transfer of materials between the chambers and one or more compartments. The mixing device may operate manually by hand-held unit. Also, this mixing device may operate automatically with at least one driving unit.

A centrifugal mixing device can include a shaft assembly that is operably coupled to a motor such that the motor rotates the shaft assembly about a first axis. The devices can further include a turret that is rotatably coupled to the shaft assembly such that the turret rotates about the first axis relative to the shaft assembly. The turret can include a first support, a first canister rotatably coupled to the first support such that the first canister rotates about a second axis, and a second canister rotatably coupled to the first support such that the second canister rotates about a third axis. The turret is configured to rotate about the first axis in a first rotational direction and each of the first and second canisters is configured to rotate about the second and third axes, respectively, in a second rotational direction that is opposite the first rotational direction.

A method for encapsulating active ingredients in liposomes having an active ingredient solution encapsulated with a bilayer composed of two monomolecular layers of amphiphilic compounds comprises: (a) providing the active ingredient solution; (b) providing an emulsion by emulsifying the active ingredient solution in a first liquid in the presence of the amphiphilic compound; (c) providing a liquid phase; (d) contacting the emulsion with the liquid phase to form a phase boundary; and (e) centrifuging the emulsion and the liquid phase that are in contact with one another via the phase boundary, wherein, on passage of the phase boundary, the amphiphilic compound enriched there is added onto the monomolecular inner layer to form a monomolecular outer layer, in order to create the bilayer.
The first liquid of the emulsion is chosen such that the solubility of the amphiphilic compound in the first liquid is not more than 1×10.sup.−4 mol/l.

A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer. The mixing tee has at least two solvent input ports and a solvent output port in fluid communication with one another. The centrifugal mixing path has a mixing path inlet in fluid communication with the solvent output port of the mixing tee. The centrifugal mixing path includes at least one coiled segment between the mixing path inlet and a mixing path outlet. The low frequency blending mixer is in fluid communication with the outlet of the centrifugal mixing path.

A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

The disclosure provides an apparatus for storing platelet-rich plasma (PRP). The apparatus is configured to reversibly receive a platelet-rich plasma (PRP) container. The apparatus comprises a platform defining at least one recess configured to receive the PRP container therein; and an agitator configured to move the platform, and thereby agitate PRP stored in the PRP container. The agitator is configured to move the platform in a circular motion at a frequency of between 10 and 10,000 revolutions per minute (RPM).

The disclosure provides an apparatus for storing platelet-rich plasma (PRP). The apparatus is configured to reversibly receive a platelet-rich plasma (PRP) container. The apparatus comprises a platform defining at least one recess configured to receive the PRP container therein; and an agitator configured to move the platform, and thereby agitate PRP stored in the PRP container. The agitator is configured to move the platform in a circular motion at a frequency of between 10 and 10,000 revolutions per minute (RPM).

A compact device compact analytical device to perform main steps of analytical procedures comprises a driving part configured to be attached to a stirrer part or a centrifuge part, wherein the stirrer part is configured to mix at least one sample and the centrifuge part is configured to separate a component. Furthermore, an analyzer part is configured to produce analytical data.

The present invention relates to a device (60) for manufacturing pharmaceutical compositions, comprising: a support (62); a mixing container (16); a plurality of reservoirs (18, 20) containing starting materials for the composition of a medicament; at least one dispensing device (64, 66) that is designed to dispense an amount of a starting material into the mixing container, wherein the dispensing device is assembled, or is designed to be assembled, with a reservoir; a stirring device (68) that is able to stir the mixing container and/or the contents of the mixing container; and an electronic module (74) for controlling the at least one dispensing device.