The present invention relates to a microfluidic device (100) for mixing liquids, wherein the microfluidic device (100) comprises a plurality of device inlets (110), each device inlet (110) for receiving a liquid; a chamber assembly (120) comprising a set of chamber inlets (122) in fluid communication with the device inlets (110); a mixing chamber (124) for receiving the liquids through the chamber inlets (122); and a plurality of chamber outlets (126) for communicating the liquids away from the mixing chamber (124); and a set of device outlets (130) in fluid communication with the chamber outlets (126), wherein the chamber outlets (126) are spaced around the mixing chamber (124) such that the mixing chamber (124) facilitates uniform mixing of the liquids communicating from the chamber inlets (122) to the chamber outlets (126). The invention also relates to a method of additive manufacturing a product comprising the microfluidic device as well as a liquid control system for controlling liquids in a microfluidic device.

The present disclosure relates to the design of structural features that enable the facile and reproducible fabrication of a microfluidic reactor that eliminates the problem of scaling factors in turn enabling the broad integration of microchannel reactors to industrial scale production. The process is highlighted via the effective and successful scale up of a purification process for the removal of a variety of different classes of impurities from crude vegetable oils mixtures into feedstocks that can be directly integrated into the hydrotreatment vegetable oil hydrogenation process for mass production of synthetic diesel derived from renewable sources.

The present disclosure relates to the design of structural features that enable the facile and reproducible fabrication of a microfluidic reactor that eliminates the problem of scaling factors in turn enabling the broad integration of microchannel reactors to industrial scale production. The process is highlighted via the effective and successful scale up of a purification process for the removal of a variety of different classes of impurities from crude vegetable oils mixtures into feedstocks that can be directly integrated into the hydrotreatment vegetable oil hydrogenation process for mass production of synthetic diesel derived from renewable sources.

A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.

An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

An object of the present invention is to provide a flow channel device which hardly generates air bubbles within a flow channel and includes: a base material having a groove; and a coating material which is integrated with the base material so as to cover the groove, in which the difference (θ1−θ2) between a contact angle (θ1) of a portion facing the groove in the coating material with respect to pure water and a contact angle (θ2) of the groove portion of the base material with respect to the pure water is −30° to 30°.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

An embodiment for a microfluidic device is provided. The device comprises two areas, arranged side-by-side, and a trigger channel. They include a first area, which is delimited by a first liquid pinning barrier, and a second area, which is delimited by a second liquid pinning barrier. The latter extends parallel to the first liquid pinning barrier to delimit a corridor. The trigger channel extends through the corridor between the two areas. In addition, the trigger channel connects the first liquid pinning barrier with the second liquid pinning barrier, allowing a first liquid pinned at the first liquid pinning barrier and a second liquid pinned at the second liquid pinning barrier to be contacted, each, by a reverse flow of the second liquid in the trigger channel and thereby start mixing at a level of the corridor, in operation. The invention is further directed to related methods of operation.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.