An apparatus and method for simple, low power, automated processing of biological samples through multiple preparation and assay steps. The apparatus and methods described facilitate the point-of-care implementation of diagnostic assays. The apparatus includes mechanical actuating elements using linear and/or rotational motion.

An apparatus and method for simple, low power, automated processing of biological samples through multiple preparation and assay steps. The apparatus and methods described facilitate the point-of-care implementation of diagnostic assays. The apparatus includes mechanical actuating elements using linear and/or rotational motion.

The present disclosure provides a microchannel device including a first base having a defining surface that defines a flow channel and containing a polymer that contains a fluorine atom and a second base having a defining surface that defines the flow channel together with the defining surface of the first base, having solvent resistance, and coming into contact with the first base, in which an arithmetic average roughness Ra of a surface of the first base, exposed by peeling the second base from the first base, is 1 μm or more, and provides a use application thereof.

An apparatus (2) for dissolving a gas into a liquid includes a liquid inlet (4) for supplying liquid into the apparatus, a gas inlet (6) for supplying gas into the liquid within the apparatus and a venturi (52) arranged to dissolve the gas into the liquid passing through the venturi. The apparatus also includes an outlet (18) for the liquid and dissolved gas downstream of the venturi. At least part of the liquid inlet, at least part of the gas inlet, at least part of the venturi and at least part of the outlet are formed in an integrally formed piece of material (42).

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

A mixer for generating particles, comprising a first mixing unit, wherein the first mixing unit comprises a first channel (702) and a second channel (701), the first channel (702) comprises a rectilinear channel, the second channel (701) comprises a curvilinear channel. The mixer is particularly suitable for producing nanoparticles, and the mixing efficiency can be improved. A microfluidic hybrid chip cartridge prepared by the mixer is also provided.

The present invention provides methods and devices for simple, low power, automated processing of biological samples through multiple sample preparation and assay steps. The methods and devices described facilitate the point-of-care implementation of complex diagnostic assays in equipment-free, non-laboratory settings.

A microfluidic device having hydrophobic and hydrophilic regions and a method of manufacture thereof are provided. The microfluidic device may include one or more channels formed using a short-pulse laser that are configured for separation or mixing of fluids. The microfluidic device may further include hydrophilic or hydrophobic surfaces configured to aid in the separation or mixture of fluids. The short-pulse laser may be a femtosecond laser.

A microfluidic device having hydrophobic and hydrophilic regions and a method of manufacture thereof are provided. The microfluidic device may include one or more channels formed using a short-pulse laser that are configured for separation or mixing of fluids. The microfluidic device may further include hydrophilic or hydrophobic surfaces configured to aid in the separation or mixture of fluids. The short-pulse laser may be a femtosecond laser.