The present invention provides modular devices and systems for infusing gas into a liquid and methods of manufacture and use thereof. In accordance with an embodiment, a modular device for infusing gas into a liquid is provided. The modular device comprises a plurality of microporous hollow fibers, and a cap covering open ends of the microporous hollow fibers. The cap is configured to receive a gas into an opening and to deliver the gas into the open ends of the microporous hollow fibers. The cap is further configured to removably mount the modular device to a fixture. A system for infusing gas into a liquid may include one or more of the modular gas infusion devices configured to be removably mounted to a fixture such that the microporous hollow fibers are within a hollow cavity. The hollow cavity includes a first opening configured to receive a liquid and a second opening configured to discharge the liquid infused with a gas. Because the system is modular, it is economical to manufacture, scale to different application requirements and to maintain.

A multi-directional contactor apparatus configured to utilize co-current and counter current flow to contact a first fluid and a second fluid, wherein the second fluid is more dense than the first fluid. The contactor comprises a chamber partially divided by a vertically extending weir, a first inlet port permitting the first fluid to enter the chamber, a second inlet port positioned above the first inlet port and permitting the second fluid to enter the chamber. Countercurrent and co-current contact of the first and second liquids occurs on one side of the weir. The weir separates the co-current contacted second fluid stream from the countercurrent contacted second fluid stream and allows the separated streams to be released from the chamber. The co-current and countercurrent contacted first fluid is released from an upper portion of the tank.

A method of manufacturing a centrifugal wheel for a mixing or pumping device with a magnetically levitated centrifugal wheel, includes providing an impeller configured to be magnetically levitated, has and having a permanent magnetic core, permanent magnetic core completely enclosed by a sheathing, the sheathing including plastic, and a plurality of blades to mix or convey substances provided on the sheathing, removing all blades from the sheathing, separating the permanent magnetic core from the sheathing, the permanent magnetic core being demagnetized before the permanent magnetic core is separated from the sheathing, attaching an encapsulation including plastic, and which completely encloses the permanent magnetic core, and attaching a plurality of vanes to the encapsulation.

A method for manufacturing a rotor for devices having a magnetically levitated rotor includes providing an impeller configured to be magnetically levitated, has and having a magnetically active core, is the magnetically active core completely enclosed by a sheathing, the sheathing comprising a plastic, and at least one impeller element configured to interact with substances is provided on the sheathing, providing a magnetization device to demagnetize or magnetize the magnetically active core, the magnetization device comprising a receptacle into which the impeller or the rotor is capable of being inserted, inserting the impeller into the receptacle and demagnetizing the magnetically active core, separating the magnetically active core from the sheathing, attaching an encapsulation to the magnetically active core, the encapsulation comprising a plastic and completely enclosing the magnetically active core, and attaching at least one conveyor element to the encapsulation.

A continuous paste mixer comprising a mixing apparatus secured to a frame is described herein. The mixing apparatus includes one or more mixer assemblies configured to extend and stack with respect to the frame, the one or more mixer assemblies to mix various ingredients (thixotropic and/or non-Newtonian) continuously and uniformly without risking uncontrolled exothermic reactions. The continuous paste mixer comprises a support member operatively connected to the mixing apparatus, and a controller configured to automatically control movement and operation of the high-shear mixer during mixing according to one or more mixing profiles.

A method, comprising: providing a substrate having present thereon a pattern of hydrophobic and hydrophilic regions; contacting a polymerizable composition to the substate so as to confer the pattern of hydrophobic and hydrophilic regions onto the polymerizable composition; and polymerizing the polymerizable composition. A device, comprising a polymeric substrate, the poly-meric substrate having disposed thereon pattern of hydrophobic and hydrophilic regions, the polymeric substrate comprising a first component that is comparatively hydrophobic relative to a second component of the composition, and a hydrophobic region of the polymeric substrate being comparatively rich in the first component relative to the second component. A method, comprising using a microfluidic device according to the present disclosure to form an emulsion.

The disclosure relates to an impeller system (1) for use with a bioreactor (2), having a drive shaft (3) configured for being rotated in a rotational direction (R) around a longitudinal axis (X) of the drive shaft by a drive motor (4) of the bioreactor; at least two impeller blades (5) connected to the drive shaft, configured for being rotated along with the drive shaft when the drive shaft is rotated, wherein the at least two impeller blades are configured for transitioning from a collapsed state to an un-collapsed state, for performing agitation. At least one of the at least two impeller blades transitions from the collapsed state to the un-collapsed state by rotating along a circumference (6) of the drive shaft due to resistance from a liquid (7) in the bioreactor when agitation is performed.

A static mixer for use with biopharmaceutical compositions includes a shell and a core. The shell defines a flow channel therethrough. The shell is formed as a lattice structure that defines a plurality of voids in fluid communication with the flow channel. The core is disposed within the flow channel of the shell. The core is configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the flow channel. The first fluid or the second fluid is a biopharmaceutical composition.