A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a vacuum port in an upper portion of the chamber, a chemical delivery system configured to inject a reactant or precursor gas into a lower portion of the chamber, a paddle assembly, and a motor to rotate a drive shaft of the paddle assembly. The lower portion of the chamber forms a half-cylinder. The paddle assembly includes a rotatable drive shaft extending through the chamber along the axial axis of the half cylinder, and a plurality of paddles extending radially from the drive shaft such that rotation of the drive shaft by the motor orbits the plurality of paddles about the drive shaft.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A mixing apparatus for mixing or stirring substances includes a mixing tank for receiving the substances, a rotor arranged in the mixing tank with which a vane for mixing or stirring the substances can be driven to rotate about an axial direction, and a stator arranged outside the mixing tank and with which the rotor can be driven contactlessly magnetically to rotate about the axial direction in the operating state and is supported magnetically with respect to the stator. A bar extends in the axial direction and is rotationally fixed to the rotor, and a limiting element fixed with respect to the mixing tank cooperates with the bar, with the limiting element being configured such that the bar rotates with respect to the limiting element and with a tilt of the rotor being limited by a physical contact between the bar and the limiting element.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A method for preparing stable liquid emulsion forms of plant extract is provided. A plant extract having a bitter flavor is mixed with diluent oil as an oil mixture and heat is applied to the oil mixture. An emulsifying agent is dispersed in water as an emulsifying solution. The oil mixture is mixed with the emulsifying solution. The mixed oil mixture and emulsifying solution is homogenized as a liquid form of the plant extract. Gluconic acid is added to the liquid form of the plant extract. The bitter flavor of the plant extract is disguised by adding a bitter blocker to the liquid form of the plant extract.

An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

A tube management system includes an elongated rack extending between a first end and an opposing second end; an elongated first shaft having a first end and an opposing second end, the first shaft being secured to the rack; a securing structure secured to the first shaft; a collapsible bag bounding a chamber; and a tubular member projecting from the collapsible bag, wherein the securing structure at least partially encircles the tubular member.

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

A system for continuous processing of powder products includes a first inlet configured to input a first dry powder product, a second inlet configured to input a second dry powder product, and a dry powder mixing device that mixes the first dry powder product together with the second dry powder product to form a product mixture. An outlet dispenses the product mixture from the dry powder mixing device. A production machine is included and has a powder feed frame comprising a feed frame inlet connected to the outlet of the dry powder mixing device. The outlet of the dry powder mixing device is positioned at a lower level than the feed frame inlet. A product conveying device is connected between the outlet of the dry powder mixing device and the feed frame inlet to continuously convey the product mixture from the dry powder mixing device to the feed frame inlet.