The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

An assembly for insertion into a holder of a mixer, comprising: a dispenser having an exterior surface of which at least a band is symmetric about a longitudinal axis of the dispenser; and an adapter for surrounding at least the band of the exterior surface of the dispenser. The adapter comprises a closeable shell, the shell being configured to lock the dispenser in at least a region of the band so as to impede rotational slippage of the dispenser relative to the adapter about the longitudinal axis with the shell being closed. If the assembly is then locked to/engaged with the holder of a planetary mixer, this causes the assembly to undergo superimposed revolution and rotation movements in tandem with those of the holder, resulting in a desired level of mixing being imparted to the dispenser's contents, which may improve homogeneity and predictability of the mixing results.

A method and system for converting a single-use liner lined bottom-mix mixing vessel to a single-use liner lined top-mix missing vessel. A bottom mount magnetic impeller drive is replaced by a top mounted impeller drive. A support frame is placed on an upper portion of the mixing vessel and has an articulated joint supporting a motor drive assembly. A top-mix single-use liner is inserted into the mixing vessel. An impeller drive shaft is inserted through a rotary hub seal in the liner to drive an internal impeller. The rotary hub seal is located by a hub lock assembly attached to the motor drive assembly.

A highly stable cannabinoid nanoparticle carrier composition for administration to a human made by incorporating non-ionic surfactants with cannabinoid oils and lipids, sonicating for a predetermined period of time at a predetermined amplification with an ultrasonic liquid processor until completely integrated; combining the mixture with a carrier fluid that includes ascorbic acid and distilled water; and further sonicating the mixture using an ultrasonic liquid processor at predetermined amplitude for a predetermined period of time at a controlled temperature, and thereby to create a CBD nanoemulsion. The composition is tailored using non-ionic surfactants to adsorb to the surface of the cannabinoid oil particles to advantageously affect electrokinetics and surface forces at the interface of the bioactive cannabinoid particles and the suspending liquid are controlled by tailoring the suspending liquid to maximize the zeta potential.

A method and system for forming a liquid mixture utilizes a mixing tank with a tank inlet oriented and configured to create a swirling liquid flow that forms a vortex within the tank. A portion of the swirling liquid is discharged through an outlet formed by an opening in a lower wall of the tank. At least a portion of the opening is offset to one side of a central axis of the lower wall. Liquid is circulated and reintroduced into the tank inlet. A material to be mixed is introduced into the swirling liquid flow within the tank interior to form a liquid mixture.

A method of producing a pharmaceutical gel emulsion, wherein the emulsion is an oil-in-water gel emulsion, comprising the steps of forming an oil-in-water emulsion comprising at least one pharmaceutically acceptable oil, at least one aqueous phase, at least one osmotic agent, at least one emulsifying agent, mixing a gelling polysaccharide with the oil-in-water emulsion and allowing the resulting mixture to form the pharmaceutical gel emulsion, optionally mixing an bioactive agent into the pharmaceutical gel emulsion.

A drug mixing device is configured to mix a first content in a liquid form in a first container and a second content in a liquid or powder form in a second container. According to an embodiment of the present disclosure, a first flow path extending from one end configured to allow a liquid inside the first container to flow into the first flow path through the one end to the other end configured to allow a liquid inside the second container to flow into the first flow path through the other end, a second flow path branching from a first branch point located on the first flow path and extending to an outlet port, and a third flow path extending to connect a second branch point located on the second flow path and a third branch point located on the first flow path are formed in the drug mixing device.

An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.

An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.