A portable system for producing a formulation comprising lipid nanoparticle (LNP)-encapsulated RNA includes: a first sub-system comprising multiple drug substance formulation modules, the first sub-system comprising: a transcription module for forming an RNA solution via in vitro transcription; and a second sub-system operatively downstream of the first sub-system comprising multiple drug product formation modules, the second sub-system comprising: an LNP formulation module for producing a first RNA-LNP preparation from the RNA solution, wherein each of the transcription module and the LNP formulation module is contained within a separate standard shipping container.

A method for the preparation of pharmaceutical products is provided that utilizes a machine having a containing liner, a dosing chamber for preparing at least one pharmaceutical product accommodated within the containing liner, and a pneumatic ventilation device for feeding two air flows through the dosing chamber and through the containing liner, respectively. Operation of the pneumatic ventilation device is selectively controlled so that the containing liner has inside a pressure lower than a pressure existing within the dosing chamber and than a pressure existing in the environment outside the containing liner itself.

A portable chemical reagent mixing device is disclosed. The portable device has stabilizing guide rails to keep the chemical reagent pack in place. The device includes a mold holding a motor which has a gear at the top that presses against a gear contained at the side of a chemical reagent pack. A power source connects to the motor by electrical wires that can be secured and concealed in the base or platform of the invention. The invention has a back guard plate that houses an adjustable spring coil in place which helps secure the reagent pack in place so that the gear of the reagent pack is pressed against the gear attached to the top of the motor to agitate the contents of a chemical reagent pack to facilitate mixing.

A filling apparatus comprises a filling material reservoir and a filling chamber that is connected to the filling material reservoir with a filling opening configured to dispense filling material into cavities in the rotary press. A first rotatably driven stirrer blade wheel with one or more stirrer blades and a second rotatably driven stirrer blade wheel with one or more stirrer blades are arranged in the filling chamber. The first rotatably driven stirrer blade wheel has at least one of a different geometry, a different direction of rotation, or a different rotary speed, than the second rotatably driven stirrer blade wheel.

The mixing or dispersing device and assembly equipped with such a device are proposed for optimizing the processing of mixed or dispersed substances, in particular tablets and/or capsules for medicinal drugs. The mixing or dispersing device includes in a mixing chamber, a motor-driven rotor having at least one cutting projection that has at least one cutting edge. A flow-disturbing element is further provided on an inner circumferential wall of the mixing chamber that surrounds the axis of rotation. Furthermore, a deflection surface is provided between the inner circumferential wall and a bottom of the mixing chamber. The at least one flow-disturbing element is spaced from the bottom of the mixing chamber, from the at least one cutting projection and from the circular path on which the at least one cutting projection is movable about the axis of rotation.

Embodiments of the method disclosed regard use of a torque sensor (e.g., transducer) and using the measured torque to detect the different fluid and mixing properties, conditions, and abnormalities in a mixing process. The torque produced in the mixing process relates to different fluid properties such as viscosity and density. It also relates to different mixing conditions such as presence of obstacles and changes or issues with gas sparging. Moreover, torque measurements enable determination of power transmitted to fluid by actual measurement, in contrast to using solely empirical impeller power number and speed, and allowing for actual mass transfer determination (i.e., gas transfer calculations).

An assembly for insertion into a holder of a mixer, comprising: a dispenser having an exterior surface of which at least a band is symmetric about a longitudinal axis of the dispenser; and an adapter for surrounding at least the band of the exterior surface of the dispenser. The adapter comprises a closeable shell, the shell being configured to lock the dispenser in at least a region of the band so as to impede rotational slippage of the dispenser relative to the adapter about the longitudinal axis with the shell being closed. If the assembly is then locked to / engaged with the holder of a planetary mixer, this causes the assembly to undergo superimposed revolution and rotation movements in tandem with those of the holder, resulting in a desired level of mixing being imparted to the dispenser’s contents, which may improve homogeneity and predictability of the mixing results.

A storage and mixing device includes a mixing compartment, two pistons that each extend from the mixing compartment and end in a displacement section, each piston defining a passageway having a first opening communicating with the mixing compartment and a second opening communicating with an inlet at the displacement section, and a housing having two piston guides and a cartridge compartment connected to the piston guide, each piston guide slidably receiving one of the pistons, and each cartridge compartment receiving a removable cartridge that includes a cavity for containing separate substances and an opening sealed by a cartridge seal. The displacement section of each piston includes a piercing member for piercing the cartridge seal of the cartridge arranged in the corresponding cartridge compartment, such that the displacement section enters the cartridge cavity and displaces the contained substance into the mixing compartment via the inlet and the passageway.

A mixing apparatus for mixing or stirring substances includes a mixing tank for receiving the substances, a rotor arranged in the mixing tank with which a vane for mixing or stirring the substances can be driven to rotate about an axial direction, and a stator arranged outside the mixing tank and with which the rotor can be driven contactlessly magnetically to rotate about the axial direction in the operating state and is supported magnetically with respect to the stator. A bar extends in the axial direction and is rotationally fixed to the rotor, and a limiting element fixed with respect to the mixing tank cooperates with the bar, with the limiting element being configured such that the bar rotates with respect to the limiting element and with a tilt of the rotor being limited by a physical contact between the bar and the limiting element.

A mixing system includes a container having an encircling sidewall bounding a chamber and extending between an upper end and an opposing lower end; a support plate disposed within the chamber and secured to the encircling sidewall; an inner wall secured to the support plate and projecting within the chamber toward the upper end, an open space being formed between the inner wall and the encircling sidewall; and a first aperture extending through the encircling sidewall so as to communicate with the open space. A mixing assembly is positioned within the container and is supported on the support plate, the mixing assembly including a pliable enclosure and a mixing device.