Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

A drug mixing container is provided. The drug mixing container includes a container with an opening facing upward and a cover body. An inner peripheral wall of the container includes at least one piercing structure protruding toward the opening of the container. The cover body accommodates a drug and includes a sealing film for sealing the drug in the cover body. In use, when an opening of the cover body is coupled downward to the opening of the container, the sealing film is pierced and torn by the piercing structure to make the drug in the cover body flow into the container, thereby preventing hands of an operator from being stained with the drug.

The present disclosure relates to a blender having blades whose orientation angle is changeable, even while the blender is in operation. The blender 100 includes a housing 110 with inlets (140a, 140b) to allow inflow of ingredients and an outlet (140c) to allow outflow of blended ingredients. The blender 100 incorporates an external shaft 122 with the blades 123 rotatably coupled to it, and an internal shaft 121 inside the external shaft 122. The blender 100 incorporates a first driving unit 130 to rotate the external shaft 122 and blades 123 about a direction along a length of the housing 110 to allow blending of the ingredients. The internal shaft 121 having engaging means coupled to back of the blades 123 such that a linear displacement of the internal shaft 121 using a second driving unit 121, enables change in orientation of the blades 123.

A method for operating a mixing apparatus of a manufacturing plant comprises supplying multiple powdered products to the mixing apparatus. An inlet mass flow rate of the multiple powdered products into the mixing apparatus and a weight of the multiple powdered products in the mixing apparatus are measured. The multiple powdered products in the mixing apparatus are mixed to form a mixed product. The weight of the multiple powdered products in the mixing apparatus and an outlet mass flow rate of the mixed product from the mixing apparatus are predicted based on the measured inlet mass flow of the multiple powdered products. The predicted outlet mass flow rate of the mixed product from the mixing apparatus is corrected based on the measured weight of the multiple powdered products in the mixing apparatus. The mixed product is processed into final products

The present disclosure relates to a reconstitution device for reconstituting a medicament, the reconstitution device comprising: a base, a carrier movably arranged on the base, and a mount for a medicament container, wherein the mount is movably arranged on the carrier.

A pharmaceutical compounding system includes a plurality of vials and a receptacle. The system is arranged to remove substances stored within the vials and combine them within the receptacle to form a medication, and each vial is continuously maintained gripped within the system during preparation of the medication.

A bioreactor system includes a support housing having an interior surface bounding a compartment. A rack is secured to the support housing in alignment with the opening. An elongated first shaft has a first end and an opposing second end, the first end of the first shaft being secured to the rack. A structure is secured to the first shaft at or towards the second end of the first shaft, the structure outwardly projecting away from the first shaft. A collapsible bag bounds a chamber and is at least partially disposed within the compartment of the support housing. A member projects from the collapsible bag and passes through the opening on the support housing, the structure supporting or restraining movement of the member.

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

A feeding and blending apparatus for a system for continuous processing of powder products comprises at least two system inlets for powder products; and at least two feeding and dosing devices arranged in a row. Each of the at least two feeding and dosing devices comprises, an inlet being connected with a system inlet, at least one feeder, at least one actuator configured to operate the at least one feeder, and an outlet being connected with an inlet of the powder blending device. A separation wall is configured to separate a process area from a technical. Process components of the at least two feeding and dosing devices are positioned in the process area and technical components of the feeding and dosing devices are positioned in the technical area. Connections between the at least one actuator and the at least one feeder pass through the separation wall.

Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.