A method for preparing stable liquid emulsion forms of plant extract is provided. A plant extract having a bitter flavor is mixed with diluent oil as an oil mixture and heat is applied to the oil mixture. An emulsifying agent is dispersed in water as an emulsifying solution. The oil mixture is mixed with the emulsifying solution. The mixed oil mixture and emulsifying solution is homogenized as a liquid form of the plant extract. Gluconic acid is added to the liquid form of the plant extract. The bitter flavor of the plant extract is disguised by adding a bitter blocker to the liquid form of the plant extract.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

A mixing system includes a container having a support plate and a mixing assembly supported on the support plate. The mixing assembly includes a pliable enclosure containing a fluid and a mixing device. A portion of the mixing device extends from the pliable enclosure and is adapted to be detachably coupled to a drive mechanism. A first plate is detachably secured to the rigid container. The pliable enclosure is disposed between the first plate and the support plate. A mixing arrangement includes a docking station having a drive cradle and a drive mechanism. The mixing system is removably positioned within the drive cradle so that the drive mechanism is removably coupled to the mixing device.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

A system for controlling an emulsification process including the steps of acquiring images such as micrographs of an emulsification process at preset intervals between a start and an end of the emulsification process; detecting selected droplet characteristics such as size and count using image segmentation such as a histogram-based technique; analyzing the measured droplet characteristics; comparing the measured droplet characteristics with a desired droplet characteristic specification; and terminating the emulsification process when said desired droplet characteristic is achieved.

Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.

A molded product production system includes a powdery material mixing and feeding device configured to feed mixed powdery materials including at least two types of powdery materials, a filler configured to fill, with the mixed powdery materials fed by the powdery material mixing and feeding device, a die bore of a compression-molding machine, a sensor configured to measure a mixing degree of the mixed powdery materials fed by the powdery material mixing and feeding device, and a molded product removal mechanism configured to distinguish a molded product obtained by compression molding mixed powdery materials having a mixing degree measured by the sensor out of a predetermined range from a molded product obtained by compression molding mixed powdery materials having a mixing degree within the predetermined range.

A method for encapsulating active ingredients in liposomes having an active ingredient solution encapsulated with a bilayer composed of two monomolecular layers of amphiphilic compounds comprises: (a) providing the active ingredient solution; (b) providing an emulsion by emulsifying the active ingredient solution in a first liquid in the presence of the amphiphilic compound; (c) providing a liquid phase; (d) contacting the emulsion with the liquid phase to form a phase boundary; and (e) centrifuging the emulsion and the liquid phase that are in contact with one another via the phase boundary, wherein, on passage of the phase boundary, the amphiphilic compound enriched there is added onto the monomolecular inner layer to form a monomolecular outer layer, in order to create the bilayer.
The first liquid of the emulsion is chosen such that the solubility of the amphiphilic compound in the first liquid is not more than 1×10.sup.−4 mol/l.

An apparatus configured to generate generating water having nano bubbles of molecular hydrogen on demand. The apparatus is connected to a water supply with a valve and has a pump which supplies pressurized water to a venturi gas liquid mixer that also receives a supply of Hydrogen gas. The mixed hydrogen gas/water steam is provided to a nano bubble generating apparatus that uses cavitation to generate nano bubbles of Hydrogen in the water. The Hydrogen nano bubbles have diameters of less than 200 nm and a concentration of up to 1.2 ppm. Further the concentration remains with 85% of the output concentration for at least 12 hours.

A module includes a housing, a sealing feature, a locking feature, and an agitator. The housing has an opening separating inner and outer surfaces and a boss that extends through the housing such that part of the outer surface forms an inner bore of the boss having a terminus pointing toward the opening. The agitator has a base, a shaft, and a mixing element coupled to the base such that the base, in cooperation with the sealing feature, circumferentially seals the opening of the housing to form a cavity defined by the inner surface. The shaft passes through the inner bore. The locking feature when engaged permits independent or simultaneous translational and rotational movement of the shaft while an area between the terminus of the boss and the shaft remains mechanically sealed during the movement against liquid or powder encroachment into a clean area of the inner bore.