An integrated microfluidic chip, wherein at least one integrated reaction unit is provided on its substrate, and the integrated reaction unit comprises at least a sample cell (1), a mixing cell (2) and a reaction cell (3) connected through liquid channels (6). In one aspect, one end of the sample cell (1) is provided with a sample inlet (4), and the chip further comprises an internal air circulating system/circuit. One end of the internal air circulating system/circuit is connected with the mixing cell (2), while the other end comprises at least a first circulation branch circuit connected with the end of the sample cell (1) distal to the sample inlet (4).

The disclosed bag for mixing materials may include a front wall, a back wall, a mixing chamber between the front wall and the back wall, a first sidewall between the front wall and the back wall and defining a first side of the mixing chamber, a second sidewall between the front wall and the back wall defining a second, opposite side of the mixing chamber, and a port positioned to provide fluid access to the mixing chamber from a bottom of the mixing chamber, wherein the first sidewall and the second sidewall are shaped to alternate a direction of fluid flow when fluid is introduced into the mixing chamber through the port. Various other components, systems, and methods are also disclosed.

A method for controlling fluid ratio accuracy during a dual flow injection with a powered injection system is described. The method includes predicting a first capacitance volume of a first syringe comprising a first medical fluid and a second capacitance volume of a second syringe comprising a second medical fluid with a first capacitance correction factor and a second capacitance correction factor, respectively, selecting a ratio of the first medical fluid and the second medical fluid to be administered to a patient in the dual flow injection, determining a relative acceleration ratio of a first piston of the first syringe and a second piston of a second syringe based on the predicted first capacitance volume and the predicted second capacitance volume, wherein the relative acceleration ratio is selected to maintain the selected ratio of the first medical fluid and the second medical fluid during the dual flow injection, and injecting a mixture of a first medical fluid and a second medical fluid having the selected ratio with the powered injection system.

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.

Microbubble production and size isolation with high yield processing. Specifically, a size isolation process is used in which a diffusion coefficient related to gas diffusion forces acting on microbubbles in suspension is controlled through maintaining diffusion parameters for the suspension. Diffusion parameters may include effective viscosity, which may be a function of microbubble volume fraction. Another diffusion parameter controlled may include temperature. In turn, microbubbles may be size isolated at high yields, which may provide for advantageous microbubble products that demonstrate increased stability for storage.

An exemplary compounding system and device for mixing materials can include a housing, a first material source and a second material source. A first fluid line can be operationally connected to the housing and configured to transport a first volume of fluid per unit time from the first material source to a final container. A second fluid line can be operationally connected to the housing and configured to transport a second volume of fluid per unit time from the second material source to the final container. The device can also include a pump system including, a first pump having a first rotor and a first platen which secures the first fluid line between the first rotor and the first platen, the first pump being configured to move the first volume of fluid through the first fluid line, and a second pump having a second rotor and a second platen which secures the second fluid line between the second rotor and the second platen, the second pump being configured to move the second volume of fluid through the second fluid line. A first platen lock can be provided and can be rotated in a first direction to lock the first platen in a closed position relative to the first rotor, and wherein rotation of the first rotor draws the first material source through the first fluid line. The pump system can also be configured such that the volume of fluid per unit time delivered by the first and second pumps is different, and/or where the first and second pumps have different head characteristics.

Systems, devices, and methods of the present disclosure assist with management of tubes and hoses during surgical procedures. The systems, devices, and methods provide for the proper opening and closing of tubes to facilitate performance of steps in a surgical procedure. Systems, devices, and methods of the present disclosure control fluid delivery to and from a medical device, including devices for tissue processing and cleaning.

The present disclosure is directed to systems and methods of providing a mixed-gas inhalant to a patient via a gas recirculation loop. The gas recirculation loop receives a first mixed-gas exhalant having a first carbon dioxide concentration from the patient, one or more carbon dioxide removal devices discharge a second mixed-gas exhalant having a second carbon dioxide concentration that is less than the first carbon dioxide concentration. The second mixed-gas exhalant is combined with a mixed-gas supply to provide a mixed-gas inhalant. The mied-gas supply includes a first gas and a second gas. The mixed-gas supply is pressure and flow controlled to produce a mixed-gas inhalant having a defined composition delivered to the patient at a defined volumetric flow rate. The first gas may include a gas containing oxygen and the second gas may include a gas mixture containing a noble or inert gas and oxygen.

A system and apparatus for opening and emptying a bag of material includes a base having a pair of opposed sides and a central aperture through which material may flow. The system includes a pair of opposed doors rotatably mounted on a pair of door shafts, the edges of the pair of opposed doors forming an opening and a plurality of piercing blades pivotally mounted to the base on a pivot rod, the blades capable of pivoting to pierce said bag. The system further includes a cutting blade mounted transversely below the opening of the opposed doors, the cutting blade capable of linear motion across the opening.