The present invention relates to a system, method, and use for the unloading of solid material particles used in a physical, chemical, and/or biological process in a tank and for the inertization of the tank. The receiving tank and the pump are fluidically connected. The inert gas supply device is fluidically connected to the tank and to at least one injector. The at least one injector is arranged along the transport line that connects the tank to the receiving tank and is configured to inject inert gas into the transport line. The pump is configured to generate negative pressure in the receiving tank and in the tank, and the inert gas supply device is configured to insert inert gas into the tank and supply inert gas to at least one injector, to allow the displacement of solid material particles from the tank to the receiving tank.

The present invention relates to a system, method, and use for the unloading of solid material particles used in a physical, chemical, and/or biological process in a tank and for the inertization of the tank. The receiving tank and the pump are fluidically connected. The inert gas supply device is fluidically connected to the tank and to at least one injector. The at least one injector is arranged along the transport line that connects the tank to the receiving tank and is configured to inject inert gas into the transport line. The pump is configured to generate negative pressure in the receiving tank and in the tank, and the inert gas supply device is configured to insert inert gas into the tank and supply inert gas to at least one injector, to allow the displacement of solid material particles from the tank to the receiving tank.

A device for producing granular materials or extrudates. The device includes a container having: an inlet for the material to be treated, an inlet for a liquid; a stirring device for producing an intermediate product from the material to be processed and the liquid; an outlet for the intermediate product; and an emptying pipe. The device includes an emptying pipe, which has: an inlet for the intermediate product; an outlet for the granular material or extrudate; and a conveying device, which conveys the intermediate product from the inlet of the emptying pipe toward the outlet of the emptying pipe, the emptying pipe, which is rotatable about an axis E-E, being arranged on the container in such a way that the emptying pipe can be moved between an open position and a closed position relative to the container.

A device for producing granular materials or extrudates. The device includes a container having: an inlet for the material to be treated, an inlet for a liquid; a stirring device for producing an intermediate product from the material to be processed and the liquid; an outlet for the intermediate product; and an emptying pipe. The device includes an emptying pipe, which has: an inlet for the intermediate product; an outlet for the granular material or extrudate; and a conveying device, which conveys the intermediate product from the inlet of the emptying pipe toward the outlet of the emptying pipe, the emptying pipe, which is rotatable about an axis E-E, being arranged on the container in such a way that the emptying pipe can be moved between an open position and a closed position relative to the container.

A tool for dry mixing and coating of powder mixtures includes a fixing shaft and an approximately disc-shaped element fixed thereto and of a diameter d, having an upper surface, a lower surface and a peripheral surface connecting the upper and lower surfaces. The disc-shaped element has a plurality of grooves extending parallel to the shaft axis. Each groove has two groove walls extending from the peripheral surface to a groove bottom. A tooth is formed between two grooves. In order to provide a tool which is suitable for particularly low contamination dry mixing, dry dispersing and coating of powder mixtures, the disc-shaped element has a base portion and at least one wear element fixed to the base portion, wherein at least one portion of each groove wall, that adjoins the peripheral surface, is formed by the wear element.

A tool for dry mixing and coating of powder mixtures includes a fixing shaft and an approximately disc-shaped element fixed thereto and of a diameter d, having an upper surface, a lower surface and a peripheral surface connecting the upper and lower surfaces. The disc-shaped element has a plurality of grooves extending parallel to the shaft axis. Each groove has two groove walls extending from the peripheral surface to a groove bottom. A tooth is formed between two grooves. In order to provide a tool which is suitable for particularly low contamination dry mixing, dry dispersing and coating of powder mixtures, the disc-shaped element has a base portion and at least one wear element fixed to the base portion, wherein at least one portion of each groove wall, that adjoins the peripheral surface, is formed by the wear element.

A particle-containing fiber bundle having high uniformity and further improved feed efficiency, and a production method of the same are provided. The particle-containing fiber bundle production method of the present invention is for producing a particle-containing fiber bundle having a prolate spheroidal shape or a strand shape, the production method including a step of mixing a plurality of shortened fibers, particles having a median diameter of 100 m or less, an organic binder, and a liquid, in which the fibers include carbon fibers, and the particles are used in an amount of 10 parts by mass or more with respect to 100 parts by mass of the fibers.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

A granulate production device and methods for open-loop and/or closed-loop control of the granulate production device. The granulate production device includes a granulator, a screening device connected to the granulator via a granulate feed line, a processing apparatus which is connected to a screen product chamber of the screening device via a granulate transfer line, and a measuring device which is suitable for detecting a physical parameter of a transfer gas. The transfer gas can be conveyed by a conveyor device arrangement on a transfer gas conveyor path extending from a feed line inlet to a transfer line outlet. The measuring device is suitable for detecting a physical parameter of the transfer gas selected from flow rate, mass flow, and flow velocity on the transfer gas conveyor path.