A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

A method of producing high strength shaped alumina by feeding alumina power into an agglomerator having a shaft with mixers able to displace the alumina power along the shaft, spraying a liquid binder onto the alumina power as it is displaced along the shaft to form a shaped alumina, and calcining the shaped alumina. The shaped alumina produced having a loose bulk density of greater than or equal to 1.20 g/ml, a surface area less than 10 m.sup.2/g, impurities of less than 5 ppm of individual metals and less than 9 ppm of impurities in total, and/or crush strength of greater than 12,000 psi.

The present invention provides a method and apparatus for agglomerating hydrophobic particles from a feed slurry. The method comprises adding a binder to a feed stream and conveying the feed stream and binder to an agglomerating device. The binder comprises 50% or more by volume of a non-hydrophobic substance. A high shear is applied to the feed stream and the binder in the agglomerating device to cause the hydrophobic particles to collide and bind to the binder, thereby agglomerating the hydrophobic particles. The agglomerated hydrophobic particles and the binder are removed from the feed stream. A method and apparatus for dewatering an agglomerated product is also provided, the agglomerated product comprising agglomerated hydrophobic particles held together by a binder comprising 50% or more by volume of a non-hydrophobic substance.

The present invention provides a method and apparatus for agglomerating hydrophobic particles from a feed slurry. The method comprises adding a binder to a feed stream and conveying the feed stream and binder to an agglomerating device. The binder comprises 50% or more by volume of a non-hydrophobic substance. A high shear is applied to the feed stream and the binder in the agglomerating device to cause the hydrophobic particles to collide and bind to the binder, thereby agglomerating the hydrophobic particles. The agglomerated hydrophobic particles and the binder are removed from the feed stream. A method and apparatus for dewatering an agglomerated product is also provided, the agglomerated product comprising agglomerated hydrophobic particles held together by a binder comprising 50% or more by volume of a non-hydrophobic substance.

A device for producing granular materials or extrudates. The device includes a container having: an inlet for the material to be treated, an inlet for a liquid; a stirring device for producing an intermediate product from the material to be processed and the liquid; an outlet for the intermediate product; and an emptying pipe. The device includes an emptying pipe, which has: an inlet for the intermediate product; an outlet for the granular material or extrudate; and a conveying device, which conveys the intermediate product from the inlet of the emptying pipe toward the outlet of the emptying pipe, the emptying pipe, which is rotatable about an axis E-E, being arranged on the container in such a way that the emptying pipe can be moved between an open position and a closed position relative to the container.

A device for producing granular materials or extrudates. The device includes a container having: an inlet for the material to be treated, an inlet for a liquid; a stirring device for producing an intermediate product from the material to be processed and the liquid; an outlet for the intermediate product; and an emptying pipe. The device includes an emptying pipe, which has: an inlet for the intermediate product; an outlet for the granular material or extrudate; and a conveying device, which conveys the intermediate product from the inlet of the emptying pipe toward the outlet of the emptying pipe, the emptying pipe, which is rotatable about an axis E-E, being arranged on the container in such a way that the emptying pipe can be moved between an open position and a closed position relative to the container.

A method for emptying a device for producing granules or extrudates. The device includes a container having an inlet for the material to be treated, an inlet for a liquid, a stirring device, an outlet for said intermediate product, and an emptying pipe having an inlet for the intermediate product and an outlet for the granules or extrudate as well as a conveying device conveying the intermediate product from the inlet of the emptying pipe in the direction of the outlet of the emptying pipe. The method includes the steps of: producing the intermediate product from the material to be treated and the liquid in the container; moving the emptying pipe from the closed position with respect to the container into an open position with respect to the container; and conveying the intermediate product from the container and via the conveying devices.