A mill dried colloidal microcrystalline cellulose (MCC) is obtained in a process comprising the steps of a) providing colloidal MCC having a moisture content of from 20 to 75 percent, based on the total weight of the moist colloidal MCC; and b) mill-drying the moist colloidal MCC in a single device capable of milling and drying in combination. The process can provide mill-dried colloidal microcrystalline cellulose having similar particle size distribution (LEFI, DIFI and EQPC), and a similar or higher tapped/untapped bulk density, a similar or lower Carr index, a similar or higher viscosity and a similar moisture content as the corresponding spray-dried colloidal microcrystalline cellulose.

A method of making cerium dioxide nanoparticles includes: a) providing an aqueous reaction mixture having a source of cerous ion, a source of hydroxide ion, a nanoparticle stabilizer, and an oxidant at an initial temperature no higher than about 20 C.; b) mechanically shearing the mixture and causing it to pass through a perforated screen, thereby forming a suspension of cerium hydroxide nanoparticles; and c) raising the initial temperature to achieve oxidation of cerous ion to eerie ion and thereby form cerium dioxide nanoparticles having a mean diameter in the range of about 1 nm to about 15 nm. The cerium dioxide nanoparticles may be formed in a continuous process.

The present disclosure relates to the cleansing of nanoparticles in aqueous cationic surfactant solutions, including polyalkylammonium salts such as cetyltrimethylammonium bromide, as demonstrated by surfactant exchange, followed by the addition of peptizing agents to stabilize the cleansed nanoparticle solutes.

Methods of performing liquid chromatography using a mobile phase and a stationary phase, wherein the stationary phase includes a separation matrix comprising spheroidal polymer beads prepared by dispersing a hydrocolloid or other gel forming compound or a water-soluble polymerizable monomer through a plurality of holes in a membrane under conditions sufficient to form beads with a volume median particle diameter of less than about 300 m and a SPAN of less than 0.6 to increase linear flow velocity (cm/h) of the mobile phase compared to polymer beads having a SPAN of 0.6 or greater are disclosed. Methods of increasing linear flow velocity of the mobile phase as well as separation matrices are further disclosed.