The present invention relates to a new process for the preparation of Panobinostat and intermediates thereof.

The present invention relates to a new process for the preparation of Panobinostat and intermediates thereof.

A preparation method and use of a novel pure inorganic solid silicon-based sulfonic acid and/or phosphoric acid catalytic material are disclosed. The surface hydroxyl-rich metasilicic acid is used as the raw material, and by using a sulfonating reagent and/or phosphoric acid, the sulfonic acid group and/or the phosphoric acid group are bonded to the inorganic silicon material by chemical bonding to obtain a pure inorganic solid silicon-based sulfonic acid and/or phosphoric acid catalytic material. The catalytic material can be widely used in many acid-catalyzed organic reactions such as isomerization, esterification, alkylation, hydroamination of olefins, condensation, nitration, etherification, multi-component reactions and oxidation reactions. The inorganic solid silicon-based sulfonic acid and/or phosphoric acid catalytic material of the present invention has the advantages of high acid amount, high activity, good hydrothermal stability, no swelling, simple preparation, low cost, no pollution, no corrosion, easy separation and reusability.

The present disclosure relates to a composition that includes a first oxide having a phosphate, a ratio of Brønsted acid sites to Lewis acid sites between 0.05 and 1.00, and a total acidity between 50 μmol/g and 300 μmol/g, where the phosphate is at least one of a functional group covalently bonded to the first oxide and/or an anion ionically bonded to the first oxide.

An electrode assembly includes a first electrode and a dielectric layer on the first electrode. The dielectric layer includes a bismuth compound of the formula Bi.sub.2(CrO.sub.4).sub.2Cr.sub.2O.sub.7, Pb.sub.4(BiO.sub.4)(PO.sub.4), Ag.sub.3BiO.sub.3, Bi.sub.2CdO.sub.2(GeO.sub.4), Bi.sub.2Te.sub.4O.sub.11, Cs.sub.6Bi.sub.4O.sub.9, Na.sub.3Bi(PO.sub.4).sub.2, Bi.sub.2(SeO.sub.3).sub.3, or a combination thereof. The electrode assembly can be particularly useful in various electronic devices.

An electrode assembly including a first electrode and a dielectric layer on the first electrode. The dielectric layer comprises a lead-containing compound of the formula PbMgV.sub.2O.sub.7, Pb.sub.2Te.sub.3O.sub.8, PbZnV.sub.2O.sub.7, Na.sub.2PbO.sub.2, PbP.sub.2O.sub.6, PbZnSiO.sub.4, Pb.sub.2In.sub.2Si.sub.2O.sub.9, Pb.sub.6(AsO.sub.4)[B(AsO.sub.4).sub.4], PbAl.sub.2Si.sub.2O.sub.8, K.sub.4PbO.sub.3, Pb.sub.2TiAs.sub.2O.sub.9, Pb.sub.4O(VO.sub.4).sub.2, Rb.sub.4PbO.sub.3, Pb.sub.2V.sub.2O.sub.7, Pb.sub.9Al.sub.8O.sub.21, Nd(Al.sub.3O.sub.6)(Pb.sub.2O.sub.2), Pb.sub.6Co.sub.9(TeO.sub.6).sub.5, Pb.sub.3(B.sub.3O.sub.7)NO.sub.3, a lead-containing oxyhalide of the formula Pb.sub.13(Cl.sub.3O.sub.5).sub.2, Pb.sub.13(Br.sub.3O.sub.5).sub.2, Pb.sub.2OF.sub.2, Pb.sub.2CO.sub.3F.sub.2, Pb(AsO.sub.2).sub.3Cl, Pb.sub.3O.sub.2(OH)Cl, Pb.sub.6(BO.sub.3).sub.3OCl, Pb.sub.2B.sub.5O.sub.9I, Pb.sub.2B.sub.5O.sub.9Br, Pb.sub.2B.sub.5O.sub.9Cl, Pb.sub.5(AsO.sub.3).sub.3Cl, Pb.sub.8Y.sub.6F.sub.32O, Pb(O.sub.2Pb.sub.3).sub.2(BO.sub.3)Br.sub.3, Pb.sub.6LaO.sub.7Cl, a lead-containing phosphate of the formula Pb.sub.2PO.sub.4I, Pb.sub.2InP.sub.3O.sub.11, Pb.sub.2MoP.sub.3O.sub.11, Pb.sub.2Ni(PO.sub.4).sub.2, Pb.sub.2VO(PO.sub.4), K.sub.2Pb(PO.sub.3).sub.4, Pb.sub.3(MoO).sub.3(PO.sub.4).sub.5, Pb.sub.4O(PO.sub.4).sub.2, RbPb(PO.sub.3).sub.3, PbVO.sub.2PO.sub.4, Pb.sub.5(PO.sub.4).sub.3F, Pb.sub.5(PO.sub.4).sub.3Cl, Pb.sub.5(PO.sub.4).sub.3I, PbP.sub.2O.sub.6, or a combination thereof. The electrode assembly can be particularly useful in various electronic devices.

Methods use a catalytic composition built up from a ceramic material including a catalytic material and a first inorganic binder and a second inorganic binder and a catalytic structure made thereof. Preferably, the structure is made by a colloidal ceramic shaping technique. The structure is used for catalytic or ion exchange applications. The catalytic structures have excellent mechanical, physicochemical and catalytic properties.

Methods use a catalytic composition built up from a ceramic material including a catalytic material and a first inorganic binder and a second inorganic binder and a catalytic structure made thereof. Preferably, the structure is made by a colloidal ceramic shaping technique. The structure is used for catalytic or ion exchange applications. The catalytic structures have excellent mechanical, physicochemical and catalytic properties.

Carbon-doped graphitic carbon nitride (g-C.sub.3N.sub.4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-C.sub.3N.sub.4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. Carbon- and phosphorus-doped g-C.sub.3N.sub.4 compositions, when in the presence of UV or visible light, can be used in water treatment systems to photocatalytically degrade persistent organic micropollutants such as pharmaceuticals and personal care products (PPCPs), endocrine disrupting compounds (EDCs), pesticides, and herbicides. Carbon- and phosphorus-doped g-C.sub.3N.sub.4 compositions can also be applied to surfaces of household and public items to kill protozoa, eukaryotic parasites, algal pathogens, bacteria, fungi, prions, viruses, or other microorganisms, preventing the transfer thereof between users.

Carbon-doped graphitic carbon nitride (g-C.sub.3N.sub.4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-C.sub.3N.sub.4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. Carbon- and phosphorus-doped g-C.sub.3N.sub.4 compositions, when in the presence of UV or visible light, can be used in water treatment systems to photocatalytically degrade persistent organic micropollutants such as pharmaceuticals and personal care products (PPCPs), endocrine disrupting compounds (EDCs), pesticides, and herbicides. Carbon- and phosphorus-doped g-C.sub.3N.sub.4 compositions can also be applied to surfaces of household and public items to kill protozoa, eukaryotic parasites, algal pathogens, bacteria, fungi, prions, viruses, or other microorganisms, preventing the transfer thereof between users.