The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.

The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.

To provide a porous silica having high alkali resistance; and a chromatographic carrier using such a porous silica. A porous silica comprising a phosphorus oxide component and a zirconium oxide component, wherein the amount of phosphorus atoms per unit specific surface area of the porous silica is from 1 μmol/m.sup.2 to 25 μmol/m.sup.2; and the amount of zirconium atoms per unit specific surface area of the porous silica is from 1 μmol/m.sup.2 to 15 μmol/m.sup.2. And, a chromatographic carrier which contains a ligand immobilized to such a porous silica.

To provide a porous silica having high alkali resistance; and a chromatographic carrier using such a porous silica. A porous silica comprising a phosphorus oxide component and a zirconium oxide component, wherein the amount of phosphorus atoms per unit specific surface area of the porous silica is from 1 μmol/m.sup.2 to 25 μmol/m.sup.2; and the amount of zirconium atoms per unit specific surface area of the porous silica is from 1 μmol/m.sup.2 to 15 μmol/m.sup.2. And, a chromatographic carrier which contains a ligand immobilized to such a porous silica.

The disclosure provides methods and kits for diagnosing the nutritional state of selenium, using six proteins as biomarkers for which the expression increases when the metabolic state is supra-nutritional.

The disclosure provides methods and kits for diagnosing the nutritional state of selenium, using six proteins as biomarkers for which the expression increases when the metabolic state is supra-nutritional.

A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

The present disclosure relates processes and systems for producing and/or purifying .sup.68Ga from an irradiated substrate of .sup.68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate .sup.68Ga from .sup.68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of .sup.68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of .sup.68Ga. In additional embodiments, the process is implemented by an automated system.

A method for preparing needle coke for ultra-high power (UHP) electrodes from heavy oil is provided. In this method, heavy oil is used as a raw material. The size exclusion chromatography (SEC) is conducted with polystyrene (PS) as a packing material to separate out specific components with a relative molecular weight of 400 to 1,000. The ion-exchange chromatography (IEC) is conducted to remove acidic and alkaline components to obtain a neutral raw material. The neutral raw material is subjected to two-stage consecutive carbonization to obtain green coke, and the green coke is subjected to high-temperature calcination to obtain the needle coke for UHP electrodes. The needle coke has a true density of more than 2.13 g/cm.sup.3 and a coefficient of thermal expansion (CTE) of ≤1.15×10.sup.−6/° C. at 25° C. to 600° C.

A method for preparing needle coke for ultra-high power (UHP) electrodes from heavy oil is provided. In this method, heavy oil is used as a raw material. The size exclusion chromatography (SEC) is conducted with polystyrene (PS) as a packing material to separate out specific components with a relative molecular weight of 400 to 1,000. The ion-exchange chromatography (IEC) is conducted to remove acidic and alkaline components to obtain a neutral raw material. The neutral raw material is subjected to two-stage consecutive carbonization to obtain green coke, and the green coke is subjected to high-temperature calcination to obtain the needle coke for UHP electrodes. The needle coke has a true density of more than 2.13 g/cm.sup.3 and a coefficient of thermal expansion (CTE) of ≤1.15×10.sup.−6/° C. at 25° C. to 600° C.