Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

A method of preparing a trihalide resin, where a trihalide ion solution is contacted with a styrene divinylbenzene polymer resin having polymer bonded -ER.sub.3.sup.+ X.sup.− groups where E is N, P, or As, R is a C.sub.2-C.sub.6 hydrocarbon group and X is Cl, Br, or I. The trihalide ion can be Cl.sub.3.sup.−, Br.sub.3.sup.−, or I.sub.3.sup.−. The trichloride resin can be used as a solid equivalent of chlorine gas. Formation of the styrene divinylbenzene resin comprising -ER.sub.3.sup.+Cl.sup.− units can be used to scavenge chlorine from a gas or liquid to form the styrene divinylbenzene resin comprising -ER.sub.3.sup.+Cl.sub.3.sup.− units. The trihalide resins can be used in disinfecting and as a source of a reagent for chemical synthesis.

A method of preparing a trihalide resin, where a trihalide ion solution is contacted with a styrene divinylbenzene polymer resin having polymer bonded -ER.sub.3.sup.+ X.sup.− groups where E is N, P, or As, R is a C.sub.2-C.sub.6 hydrocarbon group and X is Cl, Br, or I. The trihalide ion can be Cl.sub.3.sup.−, Br.sub.3.sup.−, or I.sub.3.sup.−. The trichloride resin can be used as a solid equivalent of chlorine gas. Formation of the styrene divinylbenzene resin comprising -ER.sub.3.sup.+Cl.sup.− units can be used to scavenge chlorine from a gas or liquid to form the styrene divinylbenzene resin comprising -ER.sub.3.sup.+Cl.sub.3.sup.− units. The trihalide resins can be used in disinfecting and as a source of a reagent for chemical synthesis.

The present invention relates to a bipolar ion exchange sheet and a manufacturing method therefor, the bipolar ion exchange sheet comprising: a cation exchange film comprising a cation adsorption sheet and a cation exchange coating layer formed on one side of the cation adsorption sheet; and an anion exchange film comprising an anion adsorption sheet and an anion exchange coating layer formed on one side of the anion adsorption sheet, wherein the cation exchange film and the anion exchange film are bonded so that the cation exchange coating layer and the anion exchange coating layer face each other.

The present invention relates to a bipolar ion exchange sheet and a manufacturing method therefor, the bipolar ion exchange sheet comprising: a cation exchange film comprising a cation adsorption sheet and a cation exchange coating layer formed on one side of the cation adsorption sheet; and an anion exchange film comprising an anion adsorption sheet and an anion exchange coating layer formed on one side of the anion adsorption sheet, wherein the cation exchange film and the anion exchange film are bonded so that the cation exchange coating layer and the anion exchange coating layer face each other.

A solid, ionically conductive, polymer material with a crystallinity greater than 30%; a glassy state; and both at least one cationic and anionic diffusing ion, wherein each diffusing ion is mobile in the glassy state.

A solid, ionically conductive, polymer material with a crystallinity greater than 30%; a glassy state; and both at least one cationic and anionic diffusing ion, wherein each diffusing ion is mobile in the glassy state.

A membrane capsule for biological and chemical separations comprising a cassette comprising an upper surface and a lower surface adjoined by a cassette sidewall, an inlet and an outlet located on the upper and lower surfaces of the cassette, tubes fluidly connected to the inlet and the outlet, holes or slots in the tubes to facilitate separation, and a membrane wrapped, pleated, and/or spiral wound around each of the tubes. Methods of separation comprising flowing fluid flow through the inlet of the membrane capsule, allowing the fluid to permeate through the holes or slots of the tubes, separating biological and/or non-biological substances, collecting the fluid within a reservoir, and draining fluid from the reservoir.

A cation-exchange membrane including: layer (I) containing repeating units (A) each represented by formula (1) and repeating units (S) each containing a sulfonic acid-type ion-exchange group, wherein the mass proportion of repeating units (A) based on the total mass proportion of repeating units (A) and repeating units (S) being 100% by mass is 53% by mass or more and 70% by mass or less; and layer (II) containing a fluorine-containing polymer containing a carboxylic acid-type ion-exchange group and disposed on layer (I), wherein the water content of layer (I) is 26% or more and 35% or less:

CF.sub.2—CF.sub.2  (1)

An anion exchange membrane is made by mixing 2 trifluoroMethyl Ketone [nominal] (1.12 g, 4.53 mmol), 1 BiPhenyl (0.70 g, 4.53 mmol), methylene chloride (3.0 mL). trifluoromethanesulfonic acid (TFSA) (3.0 mL) to produce a pre-polymer. The pre-polymer is then functionalized to produce an anion exchange polymer. The pre-polymer may be functionalized with trimethylamamine in solution with water. The pre-polymer may be imbibed into a porous scaffold material, such as expanded polytetrafluoroethylene to produce a composite anion exchange membrane.