The present disclosure relates processes and systems for producing and/or purifying .sup.68Ga from an irradiated substrate of .sup.68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate .sup.68Ga from .sup.68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of .sup.68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of .sup.68Ga. In additional embodiments, the process is implemented by an automated system.

Fine particles that are contained in ultrapure water supplied to a point of use is further reduced.

Ultrapure water production system has ultrapure water supply line that is connected to point of uses, wherein ultrapure water flows through ultrapure water supply line; and first ion exchange apparatus, membrane filtration apparatus and second ion exchange apparatus that are arranged in series on ultrapure water supply line. Membrane filtration apparatus is arranged between first ion exchange apparatus and second ion exchange apparatus. At least a part of the ultrapure water that flows out from membrane filtration apparatus is treated by second ion exchange apparatus before the at least a part of the ultrapure water is supplied to point of uses.

Provided herein are methods of reducing bioburden of a chromatography resin that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least on alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and a liquid including at least one alcohol, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

Provided herein are methods of reducing bioburden of a chromatography resin that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least on alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and a liquid including at least one alcohol, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

A system and method configured to restore ion exchange kinetic properties and purify resin is described. Degraded ion exchange kinetic properties of anion resin will eventually result in impurity slippage through resin charges. This system and method employs an acid catalyst in combination with sulfite cleaning solution to remove organic material and to protonate iron oxides for deconstruction and removal from anion resins. The cleaning solution, when applied via a cleaning vessel utilizing an eductor(s)/plenum and wedge-wire screen draw chamber, while controlling all phases of cleaning by electronic monitoring, yields complete restoration of ion exchange kinetics on usable resin. As such, the system and method provides a safe, effective, and vastly improved method for restoring anion resin kinetics and improving regeneration quality, for improved resin performance and minimizing resin replacement costs.

A system and method configured to restore ion exchange kinetic properties and purify resin is described. Degraded ion exchange kinetic properties of anion resin will eventually result in impurity slippage through resin charges. This system and method employs an acid catalyst in combination with sulfite cleaning solution to remove organic material and to protonate iron oxides for deconstruction and removal from anion resins. The cleaning solution, when applied via a cleaning vessel utilizing an eductor(s)/plenum and wedge-wire screen draw chamber, while controlling all phases of cleaning by electronic monitoring, yields complete restoration of ion exchange kinetics on usable resin. As such, the system and method provides a safe, effective, and vastly improved method for restoring anion resin kinetics and improving regeneration quality, for improved resin performance and minimizing resin replacement costs.

A system and method configured to restore ion exchange kinetic properties and purify resin is described. Degraded ion exchange kinetic properties of anion resin will eventually result in impurity slippage through resin charges. This system and method employs an acid catalyst in combination with sulfite cleaning solution to remove organic material and to protonate iron oxides for deconstruction and removal from anion resins. The cleaning solution, when applied via a cleaning vessel utilizing an eductor(s)/plenum and wedge-wire screen draw chamber, while controlling all phases of cleaning by electronic monitoring, yields complete restoration of ion exchange kinetics on usable resin. As such, the system and method provides a safe, effective, and vastly improved method for restoring anion resin kinetics and improving regeneration quality, for improved resin performance and minimizing resin replacement costs.

Provided are a device and a method for purifying an organic amine solution. The device includes an ion exchange bed having an upper feeding port, through which the ion exchange bed is communicated with an inert gas cylinder, a fifth liquid storage tank and a second liquid adding pump; a lower feeding port, through which the ion exchange bed is communicated with a first liquid adding pump; a lower discharging port, through which the ion exchange bed is communicated with a second liquid storage tank, a third liquid storage tank and a fourth liquid storage tank; and an upper discharging port, through which the ion exchange bed is communicated with the fourth liquid storage tank.

Provided are a device and a method for purifying an organic amine solution. The device includes an ion exchange bed having an upper feeding port, through which the ion exchange bed is communicated with an inert gas cylinder, a fifth liquid storage tank and a second liquid adding pump; a lower feeding port, through which the ion exchange bed is communicated with a first liquid adding pump; a lower discharging port, through which the ion exchange bed is communicated with a second liquid storage tank, a third liquid storage tank and a fourth liquid storage tank; and an upper discharging port, through which the ion exchange bed is communicated with the fourth liquid storage tank.

A process and apparatus for enhanced boron removal from water. The process includes the steps of reacting potassium carbonate or ammonium carbonate with calcium borate in a stream of feed water to form a stream having calcium carbonate and potassium borate salt or ammonium borate salt. The stream having calcium carbonate and potassium borate or ammonium borate is introduced to an ion exchange vessel containing resin having methylglucamine in salt form with potassium carbonate or sodium carbonate to form borate and potassium sulfate or sodium sulfate. The resin in the ion exchange vessel is periodically regenerated.