Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers at room temperature. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of sample collection.

A substrate is described having a treated contact surface comprising a carbon or silicon compound comprising from 1 to 30 atomic percent oxygen, from 0.1 to 30 atomic percent nitrogen, or both, each as measured by XPS. A method is also provided for treating a surface of a substrate. The method includes treating the surface with plasma comprising one or more non-polymerizing compounds. The treated contact surface has a biomolecule recovery percentage greater than the biomolecule recovery percentage of the surface prior to treatment according to the method.

A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

A sealed lateral flow device includes a test strip, a base structure, and a removable cover fixed to the base structure. The test strip includes one or more of a sample application zone, a detection zone, and a liquid collection zone. The test strip is disposed within a bottom section of the base structure. The removable cover fixed to the base structure sealingly encloses the test strip within the base structure and forms an airtight seal of the base structure.

Technology for a pillar structure for a biochip is disclosed. The pillar structure for a biochip includes: a substrate portion having a plate structure; an insertion pillar portion formed in one piece with the substrate portion and protruding downward from a lower surface of the substrate portion so as to be inserted into a well; and a compensation pillar portion formed in one piece with the substrate portion, the compensation pillar portion corresponding to the insertion pillar portion and protruding upward from an upper surface of the substrate portion. Therefore, when the pillar structure is cooled during an injection molding process, the substrate portion is prevented from being partially recessed, and when samples are analyzed using microscopic images, accuracy and reliability may be improved.

The disclosed technology includes a planar device for performing multiple biochemical assays at the same time, or nearly the same time. Each assay may include a biosample including a biochemical, enzyme, DNA, and/or any other biochemical or biological sample. Each assay may include one or more tags including dyes and/or other chemicals/reagents whose optical characteristics change based on chemical characteristics of the biological sample being tested. Each assay may be optically pumped to cause one or more of luminescence, phosphorescence, or fluorescence of the assay that may be detected by one or more optical detectors. For example, an assay may include two tags and a biosample. Each tag may be pumped by different wavelengths of light and may produce different wavelengths of light that is filtered and detected by one or more detectors. The pump wavelengths may be different from one another and different from the produced wavelengths.

A disposable port device for connecting a functional unit to a flexible wall of a disposable container includes a flange to be connected to the flexible wall of the disposable container and an insert providing or receiving the functional unit. The flange and the insert are separate parts made from different materials with different material characteristics. A method of manufacturing such a disposable port device includes the steps of producing the flange from a first material, producing the insert from a different second material, the first and second materials having different material characteristics, and connecting the insert to the flange.

A biological sample analysis device that is an easily portable free-standing device for determining the rate of deterioration of biological samples.

A device for safe storing and expelling of a liquid solution, including: an annular body having a proximal portion and a distal portion and including a transverse member connected along its circumference to an inner lateral surface of the annular body between the proximal portion and the distal portion of the annular body; and a liquid tight piston fitting tightly and movable within the proximal portion of the annular body, wherein the piston includes one or more longitudinal members longitudinally protruding from the piston into an interior of the proximal portion of the annular body, and wherein each of the one or more longitudinal members includes a sharp end to cut the transverse member of the annular body when the one or more longitudinal members being pushed against the transverse member of the annular body.

In a reaction or growth monitoring system, the temperature of a reaction vessel is controlled using heat from a semiconductor sensor placed in direct or thermal contact with the reaction vessel. The heat from the semiconductor sensor is controlled by monitoring the temperature at the reaction vessel and by controlling accordingly, the operation of the sensor and/or by controlling a cooling mechanism in thermal contact with the semiconductor sensor. Additional heat may be provided to the reaction vessel via electromagnetic radiation from an electromagnetic illumination source.