Disclosed herein are apparatuses comprising, for example, a microfluidic channel device comprising a main body comprising a channel configured to provide for helical fluid motion of material within the channel; and a temperature control system that applies a temperature gradient to the channel. Methods of making and using the apparatus are also described.

The present disclosure provides systems and methods for heating biological samples. Methods and systems of the present disclosure may be used for performing nucleic acid amplification to identify one or more targets in a nucleic acid sample of a subject.

The present invention discloses a convective PCR apparatus by using a transparent conductive thin film to replace the traditional metal heater. The PCR reaction is activated when the container with reagents contacted the heated transparent conductive thin film and the temperature inside the container raised to initiate the convective circulation. Also, the present invention could apply for a quantitative PCR reaction by adding a specific probe, fluorescent dye, light source, or photon receiver.

A temperature-controllable microfluidic device includes: a microfluidic channel generally extending in a first direction for passing a specimen fluid; a microheater disposed along the microfluidic channel, the microheater being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along respective sides of the microfluidic channel; and a temperature sensor disposed along the microfluidic channel, the temperature sensor being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along the respective sides of the microfluidic channel.

A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.

An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.

The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.

A device for processing a slide specimen and a method thereof, wherein the device mainly comprises a container, a base, a heating device, a slide cover plate, a slide, a slide rack, a liquid outlet, a liquid inlet, a controller, a thermocouple, a temperature display screen, a temperature maintaining time display window and a temperature maintaining time adjustment button. A large amount of slide specimens are enable to carry out processing such as reagent loading, cleaning, heat treatment, temperature maintaining and drying in one same device, realizing that there's no need to take or transfer the slide manually during the whole process of the slide specimen processing, reducing manual intervention and interference, not only saving time but also simplifying the operation steps and reducing operation errors.

Provided is a heat treatment device for slide specimen testing, and the heat treatment device mainly includes a container, a base, a heater, a liquid outlet, a liquid inlet, a controller and a thermocouple. When such device is used together with devices such as a slide cover plate and a slide rack, a large amount of slide specimens can be carried out steps of reagent loading, cleaning, heat treatment, temperature maintaining and drying inside one same device, especially multi-step operations such as an immunohistochemical testing, an original hybrid gene testing, and other protein testing, DNA nucleotide and gene testing on the slide specimen. All testing on the slide specimen is enabled to be performed in one same device from the beginning to the end, guaranteeing that all slide specimens are completely covered by the reagent from the beginning to the end, and all slide specimens are carried out the heat treatment at a uniform temperature. The operation procedures are simplified, and reliability and repeatability of slide specimen processing are enhanced.

A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.