The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

A pathogen container having a cap, a receptacle and a specimen collection member. The cap attaches to the receptacle creating a water and air tight enclosure. The receptacle has a plurality of retention members that engage with a plurality of openings in the cap to retain the cap to the receptacle. At least one alignment member on the receptacle corresponds with at least one alignment recession in the cap. The receptacle has an annular ridge extending radially outward proximate an open end of the receptacle. The cap has an annular lip that extends outward from the edge of an open end of the cap.

An automatic nucleic acid detection system and a method thereof are disclosed. The automatic nucleic acid detection method includes: performing, by an automatic control subsystem, on a nucleic acid extraction machine platform, a nucleic acid extraction on one or more specimens in a sample tray to generate one or more corresponding nucleic acids in the sample tray; distributing, by the automatic control subsystem, on a nucleic acid distribution machine platform, the nucleic acid in each hole of the sample tray and a first reagent into a plurality of holes of a detection tray, wherein the number of holes of the detection tray is greater than that of the sample tray; and performing, by the automatic control subsystem, on a nucleic acid detection machine platform, a nucleic acid detection on the detection tray.

A method of determining whether one or more forms of a nucleic acid analyte are present in a sample. The method includes dissolving an amplification reagent with a first solvent, where the amplification reagent contains oligonucleotides sufficient to amplify and detect a first region of a first form of the analyte, where the first solvent contains one or more oligonucleotides which, in combination with the oligonucleotides of the amplification reagent, are sufficient to amplify and detect a second region of a second form of the analyte, where the one or more oligonucleotides of the first solvent are insufficient to amplify and detect the first or second form of the analyte, and where the first and second regions each comprise a different nucleotide base sequence. A purified form of the sample is contacted with the dissolved amplification reagent, thereby forming an amplification reaction mixture which is exposed to temperature conditions sufficient for amplifying the first and second regions of the first and second forms of the analyte, respectively. It is then determined whether the first and/or second forms of the analyte are present in the sample.

According to an example aspect of the present invention, there is provided a liquid handling device based on air displacement principle, comprising a cavity comprising a first chamber and a second chamber, a plunger movable inside the cavity, to apply a vacuum or pressure inside the cavity, wherein the first chamber is configured to provide a first dosing volume range, wherein the second chamber together with the first chamber is configured to provide a second dosing volume range, which is larger than the first dosing volume range, wherein said first chamber and said second chamber are connected by a closable fluid connection, and wherein said fluid connection is provided through said plunger.

Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

The present invention relates to an apparatus for substantially horizontally oscillating one or more multi-well plates containing a liquid, a solid, or a mixture thereof that operates to thoroughly disrupt solid substances in multi-well plates. The apparatus provides oscillation of plates in a horizontal direction through the use of springs and rotating mechanical components. The apparatus includes a circular rotating ring having a toothed circumference that rotates horizontally, plate holder, and a spring attached to the housing and in constant contact with the plate holder. The apparatus can be used in a cold room or placed in a refrigerator to keep the substances at low temperature and to eliminate noise when the disruptor operates.

A high throughput screening apparatus having a base with channels for receiving a reagent. The channels are spaced across the surface of the base and have one or more walls which extend through the base from a first base surface to a second base surface. A compression member containing a plurality of openings extending through the compression member are positioned across the surface of the compression member, one or more of the openings being positioned for alignment with a corresponding channel in the base. A grip for removably securing the compression member to the base, when a compressible sheet is positioned across the channel between the base and the compression member and fixed by the grip, parts of the compressible sheet are compressed between the base and the compression member to form a seal between the base and the compression member, forming one or more wells for containing the reagent.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

A magazine insert for a pneumatic tube conveyor capsule for receiving sample tubes filled with bodily fluids includes a magazine drum, a fastening unit, a slider and a catch element. The magazine drum has a plurality of receiving chambers for the sample tubes. The fastening unit is pivotable about the longitudinal axis from a fastening position to a release position. The slider in the central recess of the magazine drum is slidable in axial direction from a first functional position bidirectionally to a respective second functional position relative to the magazine drum. The catch element is fastened to the slider and extends in radial direction into a control cam of the fastening unit. A pivoting of the fastening unit from the fastening position to its release position can be effected by transferring the slider to its corresponding second functional position.