A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

This system takes in raw cellular material collected using a provided swab, blood collection device, urine collection device, or other sample collection device and transforms that biological material into a digital result, identifying the presence, absence and/or quantity of nucleic acids, proteins, and/or other molecules of interest.

Provided herein are compositions and devices for diagnosing and treating a viral infection in a subject and/or detecting a viral nucleic acid in a sample. In one example, a sample is treated in a first chamber and the sample is flowed into a second chamber, where any pathogenic nucleic acid is detected by oligonucleotides that are specific to the pathogen under test. Further, the oligonucleotides comprise a cleavage site for a restriction enzyme in the second chamber, which cleaves oligonucleotide-pathogenic nucleic acid hybrid resulting in the exposure of an enzyme that was being held by the oligonucleotide to its substrate, which generates a colorimetric and/or another visual readout.

A reaction container includes a transparent base including a resin material and having recessed portions formed in one or more regions of the transparent base such that the recessed portions are recessed from a surface of the transparent base, and a cover member including a thermoplastic resin material and positioned on the transparent base such that the cover member forms a flow path including a gap extending over the recessed portions between the cover member and the surface of the transparent base and has a spacer portion welded by laser irradiation to the transparent base outside the one or more regions of the transparent base. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light such that the cover member has light transmittance in the range of from 480 nm to 570 nm.

Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

In a method for performing ultrasound tests which uses a suitable device for performing such tests, a well plate implements an insulation between the different wells of the plate of such set, without significant reflections of ultrasounds which could alter the test itself since the well plate is covered by means for closing said wells which insulates the content thereof by wholly covering the well plate and having a sound transmission speed which differs from that of the transmission liquid in the bath no more than +/−15%.

The present invention relates to a container for storing a reagent, the container comprising: a storage space for reagent (R) comprising a flexible pouch; a passage having a first end (4) that opens onto the outside of the container and a second end that opens into the storage space, the passage being designed to allow a sampling device (20) to access the storage space; a deformable partition (7) that closes off the passage when said partition is not mechanically loaded and which can be loaded by the sampling device to a position in which the passage is open; a seal (6) that is positioned in the passage and comprises an elastically deformable rim (64) defining an orifice (61) that is designed to receive part of the sampling device (20), said rim (64) being designed to establish a seal together with the outer walls of the sampling device when said device is introduced into the passage.

Stable operation of an ultrasonic vibrator of an ultrasonic cleaner and scattering prevention of a washing liquid are provided. The ultrasonic cleaner includes a washing tank 206 in which a washing liquid is reserved; an ultrasonic vibrator 205; a vibration head 209 provided with a neck 304 extended from the ultrasonic vibrator to the washing tank and a tip end portion 210 having a cylindrical hole 211 whose longitudinal direction is oriented to a perpendicular direction; and a first cover 601 having an opening corresponding to the neck and the cylindrical hole, in which the first cover is arranged to a height in contact with a liquid surface of the washing liquid such that it covers the washing tank.

A reaction container including a transparent base having a first surface having at least one region where recessed portions are formed and recessed from the first surface, and a cover member positioned such that the cover member forms a gap from the first surface inside the region and is welded to the transparent base outside the region. The cover member absorbs infrared light and transmits light having a wavelength within a range of visible light.