An apparatus for limiting pipette motion, the apparatus comprising: (1) a stand for controlling spatial positions; (2) a mechanism for temporally coupling the pipette with the stand; the orientation or the movement of the pipette being restricted by the stand as predetermined for (a) limiting the insertion depth of the pipette tips into sample containers, (b) restricting unwanted movements or rotations of the pipette, or (c) maintaining the desired alignments of the pipette tips with the sample containers. Methods of limiting pipette motion or rotation are also provided.

The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

A digital microfluidic device, comprising a bottom plate and a top plate. The bottom plate comprises a bottom electrode array comprising a plurality of digital microfluidic propulsion electrodes. The top plate comprises a segmented top electrode array comprising a plurality of separately voltage addressable top electrode segments. Each top electrode segment and at least two of the propulsion electrodes of the bottom electrode array form a zone within the device. A controller is operatively coupled to the top electrode array and to the bottom electrode array and is configured to provide propulsion voltages between the top plate segment and the bottom plate propulsion electrodes of at least one of the zones. The top plate and the bottom plate are provided in a spaced relationship defining a microfluidic region therebetween.

The present disclosure provides a microfluidic device and a manufacturing method therefor, and a method for detecting the number of biomolecules and a system for detecting the number of biomolecules. The microfluidic device includes a glass substrate; a plurality of first metal strips formed on the glass substrate; a photoresist covering the plurality of first metal strips; a fluid cavity formed in the photoresist; a plurality of second metal strips formed on the photoresist, wherein a head end of one first metal strip and a tail end of the other first metal strip in any adjacent two first metal strips are electrically coupled through a head end and a tail end of one second metal strip between the two first metal strips, so that the plurality of first metal strips and the plurality of second metal strips form a hollow inductor structure around the fluid cavity.

A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.

The present invention discloses a device and a method for capillary chemiluminescence detection. The device comprises a liquid adding device, wherein the liquid adding device comprises: a bottom end of a funnel cup connected to a top end of the capillary body; a mounting bracket with one or more grooves; a liquid reagent cup disposed in each of the one or more grooves, a reagent set in the cup body, and a sealing film disposed at the opening of the cup body, a bottom end of each of the one or more grooves is connected to a top end of the funnel cup; a puncture device disposed in an inner bottom end of each of the one or more grooves. The present invention has the advantages of reducing the cost of the instrument, improving the reliability of the operation and so on.

An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.

Provided is a microfluidic chip having an inlet/outlet structure optimized for sealing an inlet/outlet of a microfluidic chip using a UV curable sealing material, a microfluidic chip having the inlet/outlet structure, and a method of sealing the inlet/outlet of the microfluidic chip using a UV curable sealing material. It is possible to provide a semi-permanent seal with less contamination from a fluid sample or a harmful reagent, and the inlet/outlet of the microfluidic chip can be firmly sealed using simple equipment and without high-temperature/high-pressure conditions. By using the inlet/outlet structure of the microfluidic chip and the sealing method thereof, it is possible not only to improve the accuracy and deviation of the reaction result as the generation of bubbles is suppressed even when a predetermined reaction is performed on the microfluidic chip, but also it is possible to apply a fully automated system by eliminating the need for ancillary equipment such as a chip case and minimizing or eliminating manual operations.

A chip for gene sequencing and a gene sequencing method are disclosed. The chip for gene sequencing includes: a body, including an accommodating chamber and a temperature testing element, wherein the temperature testing element is configured for testing a temperature variation amount in the accommodating chamber.

The invention relates to a method of manipulating droplets in a channel area, comprising: providing a flow of carrier fluid in the channel area; providing at least one droplet of a first fluid and at least one droplet of a second fluid within the carrier fluid, the first fluid and the second fluid being immiscible with the carrier fluid; displacing the droplet of first fluid and the droplet of second fluid along the channel area, successively (a) by a flow of carrier fluid in a first direction and at a first flow rate; and (b) by a flow of carrier fluid in a second direction opposite to the first direction, and at a second flow rate different from the first flow rate.