A corrugated constant pressure cylinder apparatus having no micro leaks and its method of use. The internal pressure of the corrugated cylinder (b10) is maintained at a constant pressure so as to allow for transport or storage in a state without micro leaks. The corrugated constant pressure cylinder apparatus is able to keep substances that exist in gaseous or liquid form at room temperature such as mixed refrigerant gases, volatile organic compounds (VOC), hydrocarbon mixtures-in liquid form, or is able to keep the pressure constant even if the internal volume changes due to the contents inside the cylinder.

The invention relates to a laboratory cabinet device for storing laboratory samples with a magnetic closure for the door. It in particular relates to a tempering cabinet for tempering laboratory samples, in particular, an incubator for the growth of cell cultures.

An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.

Organ-on-chip platforms with reduced fluid volumes include circulating fluid volumes of below 1000 L, preferably about 500 L or less. The platforms are adjustable for culturing cells with varied oxygen demand at various seeding densities. The platforms include at least one lane, wherein each lane includes at least one cell culture well, at least one oxygenator for fluid oxygenation, and a pump system containing at least one pump per lane. The oxygenator may include a separate fluid path for oxygenating the fluid, which allows controlling and measuring the oxygen concentration in the fluid, shortening the diffusion length, and passively diffusing oxygen. Provided are also different configurations for the oxygenator, fluid circulation in the platforms, attachment means for securing scaffolds to culture wells, and pneumatic plates.

A desorber for a trace detection system. The desorber includes an inlet configured to receive a sample, a heating element configured to generate a vapor from the sample, and an active cooling element configured to cool the desorber.

A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.

A skewer-type gripper for one-sidedly receiving a test sample positioned in a defined manner and still compressed by plungers in a punching device and consisting of viscoelastic materials with an upper side and an edge area. The gripper has a base and skewer-type means arranged in a plane therein, which can pierce into the edge area of the still compressed test sample parallel to the upper side. The skewer-type means are configured in such a way that the test sample can be received and held in a torque-proof manner by the skewer-type means. The gripper is configured and set up for horizontally receiving the test sample from a punching device, and the gripper or skewer-type means can be exposed to a feed force for this purpose.

A closure (10, 100, 150) for a labware device (20). The labware device (20) defines an interior chamber (25) having at least one opening (92). The closure (10, 100, 150) includes a closure body (12, 102) configured to be mounted to the labware device (20) and in fluid communication with the opening (92). A vent valve (14, 122) is mounted for movement relative to the closure body (12, 102). The vent valve (14, 122), with the closure body (12, 102), defines a space (72, 120) that defines a path between the closure body (12, 102) and the vent valve (14, 122) for gas exchange between the interior chamber (25) and the exterior of the labware device (20). A filter (50) is positioned within the space (72, 120) and is configured to filter contaminants from gas entering the interior chamber (25) via the path.

An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.

Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.