An analyte identifying and sorting apparatus for sorting a target analyte based on an identification result of analytes dispersed in a liquid. The apparatus includes an identification unit including an analyte storage section configured to store analytes dispersed in a liquid, a pressure control section configured to feed the liquid to a flow path provided to extend downward from the analyte storage section, a light irradiation section configured to irradiate light to the analytes, an optical information measurement section measuring optical information of the analytes, and a determination section determining whether the analyte is a target analyte or a non-target analyte based on the optical information. Also included is a sorting unit that includes a sorting nozzle connected to the identification unit and sorts a sorted solution containing the target analyte to the vessel, an effluent collection section having a suction nozzle to suck and collect an effluent involving an effluent discharged from a tip of the sorting nozzle, and a collection vessel configured to collect the sorted solution containing the target analyte. A moving unit moves the sorting nozzle and/or the collection vessel, a control unit moves the sorting nozzle and/or the collection vessel based on the optical information, and a stirring unit including a stirring member in an inner space of the analyte storage section.

A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

A reaction processor includes: a reaction processing vessel placing portion for placing a reaction processing vessel provided with a channel into which a sample is introduced; a temperature control system, which controls the temperature of the channel in order to heat the sample inside the channel; and a liquid feeding system, which controls the pressure inside the channel of the reaction processing vessel in order to move the sample inside the channel. The liquid feeding system maintains the pressure inside the channel to be higher than the atmospheric pressure in the surrounding of the reaction processing vessel, more preferably 1 atm or higher, during a reaction process of the sample.

A biosensor for detecting analytes present in fluid includes one or more plates configured on a substrate to form at least one channel such that one or more containment chambers are formed in the channels. The channel are mechanically, separated from each other by spacers, and the containment chambers are fluidically separated from adjacent chamber by a discontinuity such that the fluid flows between adjacent chambers only after an application of a predefined pressure on the plate. The multiple chambers allows the fluid to undergo pre-processing using different set of reagents provided at different chambers, to mitigate effects of interferents and to efficiently distribute load of the reagents on the chambers. Further, some of containment chambers allows detection of analytes in the fluid using detection reagents.

A microfluidic apparatus for delivering droplets of a first fluid to droplets of a second fluid, comprising a main channel, with a carrier fluid carrying droplets of the second fluid, an auxiliary channel, fluidly coupled to the main channel at a first intersection via a first orifice with a first fluid interface, and at a second intersection downstream to the first intersection via a second orifice with a second fluid interface, wherein a flow of the carrier fluid induces a difference of pressure between the first and second orifice generating a balance condition such that a meniscus of the second fluid interface is maintained in the auxiliary channel, at the vicinity of the second orifice, wherein a balance deviation triggers a release of a volume of the first fluid from the second fluid interface into the main channel.

A system for conducting urinalysis of urine is provided. The system includes a housing mountable on a urination device defining urination area; a dispenser mounted in the housing and being configured for holding a plurality of urine test strips (hereinafter “UTS”). Each one of the UTS includes at least one reacting area configured for a chemical reaction with a substance in the urine. The system further includes a detector configured for detecting at least one property of the reacting area and a shifting mechanism configured for extracting one UTS from the dispenser and moving the UTS to a urination position in which the UTS is disposed above the urination area, such that the reacting area is disposed along a urine path.

Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.

Microfluidic device comprising a tank (6) supplying a microchannel (2) with a first fluid (S), and a circuit (8) in which a flow of a second fluid can be established without contact with the microchannel (2). The circuit (8) passes through the tank (6) or is connected to the tank (6) by a pipe (30). The circuit (8) comprises a first on/off valve (12) mounted in parallel with a first proportional valve (11), these first valves (11, 12) being controllable so as to modify the pressure applied in the tank (6) to the first fluid (S) by the second fluid.

An apparatus (1) for ex-vivo measurement of performance of a donor heart (2) has a heart holder (6) in a receptacle (7) for holding a human donor heart and a bag (17) for placement into a left ventricle of the heart. The bag has a bag interior space communicating with an interior space of a fluid tight, compressible and expandable container (19. The apparatus further includes a sensor (21) for measuring compression and expansion of the container. Using the apparatus cardiac outwit can be measured by measuring expansion and contraction of the container. A method for ex-vivo measurement of performance of a donor heart is also described. The method may include controlling the preload and/or the afterload.

An embodiment of an assembly for isolating a substrate is described that comprises a vacuum source; a substrate; a receptacle configured to position the substrate and to operatively couple to the vacuum source; and a vessel configured to operatively coupled to the receptacle, wherein the substrate is configured to move from the receptacle to the vessel in response to a differential pressure applied by the vacuum source.